Demonstration of the efficacy of statins in resolution of plaque inflammation by serial FDG imaging

Nobuhiro Tahara, Sho Ichi Yamagishi, Minori Mizoguchi, Takeshi Kondo, Hisashi Kai, Tsutomu Imaizumi, Jagat Narula

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Statins contribute to stabilization of atherosclerotic plaques not only by reduction in circulating levels of atherogenic lipoproteins, but also by pleiotropic effects such as resolution of plaque inflammation. 18F-fluorodeoxyglucose (FDG) imaging, which is commonly employed for the detection of malignant tumors, has been recently shown to identify inflamed atherosclerotic lesions, and prospective studies have demonstrated close relationship between FDG uptake and the extent of vascular inflammation. The FDG uptake is highly reproducible. Use of statins abrogates FDG uptake, suggesting favorable effect on plaque inflammation. Recent demonstration of FDG uptake in coronary vessels suggests that detection of vulnerable plaques may become a possibility.

Original languageEnglish
Pages (from-to)183-188
Number of pages6
JournalImmunology, Endocrine and Metabolic Agents in Medicinal Chemistry
Volume8
Issue number2
DOIs
StatePublished - Jun 2008
Externally publishedYes

Keywords

  • Atherosclerosis
  • HMG-CoA reductase inhibitor
  • Molecular imaging
  • Position emission tomography

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