Dementia with coexistent major depression

B. S. Greenwald, E. Kramer-Ginsberg, D. B. Marin, L. B. Laitman, C. K. Hermann, R. C. Mohs, K. L. Davis

Research output: Contribution to journalArticlepeer-review

118 Scopus citations


Eleven percent (N = 25) of 232 dementia patients seen in an active geropsychiatry service also met criteria for major depression. Ten patients with dementia/depression were prospectively compared with 10 nondepressed demented and 33 nondemented depressed patients on pretreatment and posttreatment ratings of depression and copgnition/memory. Seventy percent (N = 7) of the dementia/depression group and 73% (N = 24) of the depression-only group responded to antidepressant therapy. Signs and symptoms of depression complicating dementia were similar to depressive phenomena in the depression-only group. Depression with dementia appeared to lower performance on cognitive tests. Following treatment, althoug cognitive impairment remained in the demented range, test performance improved.

Original languageEnglish
Pages (from-to)1472-1478
Number of pages7
JournalAmerican Journal of Psychiatry
Issue number11
StatePublished - 1989


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