Degradation of poly(ester) microspheres

H. T. Wang; H. Palmer; R. J. Linhardt; D. R. Flanagan; E. Schmitt

doi:10.1016/0142-9612(90)90026-M

Degradation of poly(ester) microspheres

H. T. Wang, H. Palmer, R. J. Linhardt, D. R. Flanagan, E. Schmitt

Research output: Contribution to journal › Article › peer-review

121 Scopus citations

Abstract

Biodegradable polymeric microspheres have been prepared by spray drying, precipitation, rotary evaporation and press grinding methods. Erosion of microspheres of poly(lactide), poly(3-hydroxybutyrate), copolymers of lactide and glycolide, and copolymers of 3-hydroxybutyrate and 3-hydroxyvalerate at 85°C and 37°C have been studied using ion chromatography, nuclear magnetic resonance, residual mass measurements, viscometry and gel permeation chromatography. Such studies demonstrated that these polyester matrices degraded via (1) random chain scission and (2) release of soluble monomeric and oligomeric products. Protein release from microspheres prepared by these methods indicated that most of the protein is released before the polymer matrix loses weight.

Original language	English
Pages (from-to)	679-685
Number of pages	7
Journal	Biomaterials
Volume	11
Issue number	9
DOIs	https://doi.org/10.1016/0142-9612(90)90026-M
State	Published - Nov 1990
Externally published	Yes

Keywords

Microspheres
biodegradation
poly(esters)

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10.1016/0142-9612(90)90026-M

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title = "Degradation of poly(ester) microspheres",

abstract = "Biodegradable polymeric microspheres have been prepared by spray drying, precipitation, rotary evaporation and press grinding methods. Erosion of microspheres of poly(lactide), poly(3-hydroxybutyrate), copolymers of lactide and glycolide, and copolymers of 3-hydroxybutyrate and 3-hydroxyvalerate at 85°C and 37°C have been studied using ion chromatography, nuclear magnetic resonance, residual mass measurements, viscometry and gel permeation chromatography. Such studies demonstrated that these polyester matrices degraded via (1) random chain scission and (2) release of soluble monomeric and oligomeric products. Protein release from microspheres prepared by these methods indicated that most of the protein is released before the polymer matrix loses weight.",

keywords = "Microspheres, biodegradation, poly(esters)",

author = "Wang, {H. T.} and H. Palmer and Linhardt, {R. J.} and Flanagan, {D. R.} and E. Schmitt",

year = "1990",

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T1 - Degradation of poly(ester) microspheres

AU - Wang, H. T.

AU - Palmer, H.

AU - Linhardt, R. J.

AU - Flanagan, D. R.

AU - Schmitt, E.

PY - 1990/11

Y1 - 1990/11

N2 - Biodegradable polymeric microspheres have been prepared by spray drying, precipitation, rotary evaporation and press grinding methods. Erosion of microspheres of poly(lactide), poly(3-hydroxybutyrate), copolymers of lactide and glycolide, and copolymers of 3-hydroxybutyrate and 3-hydroxyvalerate at 85°C and 37°C have been studied using ion chromatography, nuclear magnetic resonance, residual mass measurements, viscometry and gel permeation chromatography. Such studies demonstrated that these polyester matrices degraded via (1) random chain scission and (2) release of soluble monomeric and oligomeric products. Protein release from microspheres prepared by these methods indicated that most of the protein is released before the polymer matrix loses weight.

AB - Biodegradable polymeric microspheres have been prepared by spray drying, precipitation, rotary evaporation and press grinding methods. Erosion of microspheres of poly(lactide), poly(3-hydroxybutyrate), copolymers of lactide and glycolide, and copolymers of 3-hydroxybutyrate and 3-hydroxyvalerate at 85°C and 37°C have been studied using ion chromatography, nuclear magnetic resonance, residual mass measurements, viscometry and gel permeation chromatography. Such studies demonstrated that these polyester matrices degraded via (1) random chain scission and (2) release of soluble monomeric and oligomeric products. Protein release from microspheres prepared by these methods indicated that most of the protein is released before the polymer matrix loses weight.

KW - Microspheres

KW - biodegradation

KW - poly(esters)

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DO - 10.1016/0142-9612(90)90026-M

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JO - Biomaterials

JF - Biomaterials

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ER -

Degradation of poly(ester) microspheres

Abstract

Keywords

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