Degradation of poly(ester) microspheres

H. T. Wang, H. Palmer, R. J. Linhardt, D. R. Flanagan, E. Schmitt

Research output: Contribution to journalArticlepeer-review

120 Scopus citations


Biodegradable polymeric microspheres have been prepared by spray drying, precipitation, rotary evaporation and press grinding methods. Erosion of microspheres of poly(lactide), poly(3-hydroxybutyrate), copolymers of lactide and glycolide, and copolymers of 3-hydroxybutyrate and 3-hydroxyvalerate at 85°C and 37°C have been studied using ion chromatography, nuclear magnetic resonance, residual mass measurements, viscometry and gel permeation chromatography. Such studies demonstrated that these polyester matrices degraded via (1) random chain scission and (2) release of soluble monomeric and oligomeric products. Protein release from microspheres prepared by these methods indicated that most of the protein is released before the polymer matrix loses weight.

Original languageEnglish
Pages (from-to)679-685
Number of pages7
Issue number9
StatePublished - Nov 1990
Externally publishedYes


  • Microspheres
  • biodegradation
  • poly(esters)


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