@inproceedings{e6463516eb784e8c93daf86584a5a3b2,
title = "Deformable and reconfigurable mouse phantoms with 3D printing and LTS technologies",
abstract = "Mice are used for models of almost all human diseases and are routinely scanned by micro-CT scanners. Mouse phantoms are often used for image-quality assessment. With recent developments in deep-learning-based preclinical imaging, there is a major need for large micro-CT datasets in which ground truth is known. In this study, we investigate the feasibility of making cost-effective deformable and reconfigurable mouse phantoms to generate real micro-CT datasets that reflect realistic underlying physical characteristics. Such datasets are highly desirable; for example, complicated photon-counting micro-CT datasets are needed for deep-learning-based material decomposition. In our scheme, mouse body parts are 3Dprinted with high precision using rigid or flexible materials. Liquid tissue surrogates (LTSs) or bioinks/cell lines could be used to emulate mouse organs and physiological fluid in the animals. LTSs provide realistic x-ray properties of their biological counterparts. The LTS organs could be contained in not only 3D-printed chambers, but also dialysis tubing, which emulates the cell membrane. Furthermore, through bioprinting and tissue engineering, organs and tissues can be made even more realistic for micro-CT and other types of tomographic scanning.",
keywords = "3D printing, Liquid tissue surrogate (LTS), Micro-CT, Mouse phantom, Small animal imaging",
author = "Hannah Wang and Mengzhou Li and Matthew Getzin and Arduini, {Brigitte L.} and Nathaniel Covert and Deepak Vashishth and Paul Fitzgerald",
note = "Publisher Copyright: {\textcopyright} COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.; 12th SPIE Conference on Developments in X-Ray Tomography 2019 ; Conference date: 13-08-2019 Through 15-08-2019",
year = "2019",
doi = "10.1117/12.2530770",
language = "English",
series = "Proceedings of SPIE - The International Society for Optical Engineering",
publisher = "SPIE",
editor = "Bert Muller and Ge Wang",
booktitle = "Developments in X-Ray Tomography XII",
address = "United States",
}