Deformable and reconfigurable mouse phantoms with 3D printing and LTS technologies

Hannah Wang, Mengzhou Li, Matthew Getzin, Brigitte L. Arduini, Nathaniel Covert, Deepak Vashishth, Paul Fitzgerald

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

Mice are used for models of almost all human diseases and are routinely scanned by micro-CT scanners. Mouse phantoms are often used for image-quality assessment. With recent developments in deep-learning-based preclinical imaging, there is a major need for large micro-CT datasets in which ground truth is known. In this study, we investigate the feasibility of making cost-effective deformable and reconfigurable mouse phantoms to generate real micro-CT datasets that reflect realistic underlying physical characteristics. Such datasets are highly desirable; for example, complicated photon-counting micro-CT datasets are needed for deep-learning-based material decomposition. In our scheme, mouse body parts are 3Dprinted with high precision using rigid or flexible materials. Liquid tissue surrogates (LTSs) or bioinks/cell lines could be used to emulate mouse organs and physiological fluid in the animals. LTSs provide realistic x-ray properties of their biological counterparts. The LTS organs could be contained in not only 3D-printed chambers, but also dialysis tubing, which emulates the cell membrane. Furthermore, through bioprinting and tissue engineering, organs and tissues can be made even more realistic for micro-CT and other types of tomographic scanning.

Original languageEnglish
Title of host publicationDevelopments in X-Ray Tomography XII
EditorsBert Muller, Ge Wang
PublisherSPIE
ISBN (Electronic)9781510629196
DOIs
StatePublished - 2019
Externally publishedYes
Event12th SPIE Conference on Developments in X-Ray Tomography 2019 - San Diego, United States
Duration: 13 Aug 201915 Aug 2019

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume11113
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Conference

Conference12th SPIE Conference on Developments in X-Ray Tomography 2019
Country/TerritoryUnited States
CitySan Diego
Period13/08/1915/08/19

Keywords

  • 3D printing
  • Liquid tissue surrogate (LTS)
  • Micro-CT
  • Mouse phantom
  • Small animal imaging

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