Defining trained immunity and its role in health and disease

Mihai G. Netea; Jorge Domínguez-Andrés; Luis B. Barreiro; Triantafyllos Chavakis; Maziar Divangahi; Elaine Fuchs; Leo A.B. Joosten; Jos W.M. van der Meer; Musa M. Mhlanga; Willem J.M. Mulder; Niels P. Riksen; Andreas Schlitzer; Joachim L. Schultze; Christine Stabell Benn; Joseph C. Sun; Ramnik J. Xavier; Eicke Latz

doi:10.1038/s41577-020-0285-6

Defining trained immunity and its role in health and disease

Mihai G. Netea
, Jorge Domínguez-Andrés
, Luis B. Barreiro
, Triantafyllos Chavakis
, Maziar Divangahi
, Elaine Fuchs
, Leo A.B. Joosten
, Jos W.M. van der Meer
, Musa M. Mhlanga
, Willem J.M. Mulder
, Niels P. Riksen
, Andreas Schlitzer
, Joachim L. Schultze
, Christine Stabell Benn
, Joseph C. Sun
, Ramnik J. Xavier
, Eicke Latz

Research output: Contribution to journal › Review article › peer-review

2155 Scopus citations

Abstract

Immune memory is a defining feature of the acquired immune system, but activation of the innate immune system can also result in enhanced responsiveness to subsequent triggers. This process has been termed ‘trained immunity’, a de facto innate immune memory. Research in the past decade has pointed to the broad benefits of trained immunity for host defence but has also suggested potentially detrimental outcomes in immune-mediated and chronic inflammatory diseases. Here we define ‘trained immunity’ as a biological process and discuss the innate stimuli and the epigenetic and metabolic reprogramming events that shape the induction of trained immunity.

Original language	English
Pages (from-to)	375-388
Number of pages	14
Journal	Nature Reviews Immunology
Volume	20
Issue number	6
DOIs	https://doi.org/10.1038/s41577-020-0285-6
State	Published - 1 Jun 2020

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Netea, M. G., Domínguez-Andrés, J., Barreiro, L. B., Chavakis, T., Divangahi, M., Fuchs, E., Joosten, L. A. B., van der Meer, J. W. M., Mhlanga, M. M., Mulder, W. J. M., Riksen, N. P., Schlitzer, A., Schultze, J. L., Stabell Benn, C., Sun, J. C., Xavier, R. J., & Latz, E. (2020). Defining trained immunity and its role in health and disease. Nature Reviews Immunology, 20(6), 375-388. https://doi.org/10.1038/s41577-020-0285-6

@article{6c55a35aaae64e10890cd7c869d2e755,

title = "Defining trained immunity and its role in health and disease",

abstract = "Immune memory is a defining feature of the acquired immune system, but activation of the innate immune system can also result in enhanced responsiveness to subsequent triggers. This process has been termed {\textquoteleft}trained immunity{\textquoteright}, a de facto innate immune memory. Research in the past decade has pointed to the broad benefits of trained immunity for host defence but has also suggested potentially detrimental outcomes in immune-mediated and chronic inflammatory diseases. Here we define {\textquoteleft}trained immunity{\textquoteright} as a biological process and discuss the innate stimuli and the epigenetic and metabolic reprogramming events that shape the induction of trained immunity.",

author = "Netea, \{Mihai G.\} and Jorge Dom{\'i}nguez-Andr{\'e}s and Barreiro, \{Luis B.\} and Triantafyllos Chavakis and Maziar Divangahi and Elaine Fuchs and Joosten, \{Leo A.B.\} and \{van der Meer\}, \{Jos W.M.\} and Mhlanga, \{Musa M.\} and Mulder, \{Willem J.M.\} and Riksen, \{Niels P.\} and Andreas Schlitzer and Schultze, \{Joachim L.\} and \{Stabell Benn\}, Christine and Sun, \{Joseph C.\} and Xavier, \{Ramnik J.\} and Eicke Latz",

note = "Publisher Copyright: {\textcopyright} 2020, Springer Nature Limited.",

year = "2020",

month = jun,

day = "1",

doi = "10.1038/s41577-020-0285-6",

language = "English",

volume = "20",

pages = "375--388",

journal = "Nature Reviews Immunology",

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Netea, MG, Domínguez-Andrés, J, Barreiro, LB, Chavakis, T, Divangahi, M, Fuchs, E, Joosten, LAB, van der Meer, JWM, Mhlanga, MM, Mulder, WJM, Riksen, NP, Schlitzer, A, Schultze, JL, Stabell Benn, C, Sun, JC, Xavier, RJ & Latz, E 2020, 'Defining trained immunity and its role in health and disease', Nature Reviews Immunology, vol. 20, no. 6, pp. 375-388. https://doi.org/10.1038/s41577-020-0285-6

TY - JOUR

T1 - Defining trained immunity and its role in health and disease

AU - Netea, Mihai G.

AU - Domínguez-Andrés, Jorge

AU - Barreiro, Luis B.

AU - Chavakis, Triantafyllos

AU - Divangahi, Maziar

AU - Fuchs, Elaine

AU - Joosten, Leo A.B.

AU - van der Meer, Jos W.M.

AU - Mhlanga, Musa M.

AU - Mulder, Willem J.M.

AU - Riksen, Niels P.

AU - Schlitzer, Andreas

AU - Schultze, Joachim L.

AU - Stabell Benn, Christine

AU - Sun, Joseph C.

AU - Xavier, Ramnik J.

AU - Latz, Eicke

PY - 2020/6/1

Y1 - 2020/6/1

N2 - Immune memory is a defining feature of the acquired immune system, but activation of the innate immune system can also result in enhanced responsiveness to subsequent triggers. This process has been termed ‘trained immunity’, a de facto innate immune memory. Research in the past decade has pointed to the broad benefits of trained immunity for host defence but has also suggested potentially detrimental outcomes in immune-mediated and chronic inflammatory diseases. Here we define ‘trained immunity’ as a biological process and discuss the innate stimuli and the epigenetic and metabolic reprogramming events that shape the induction of trained immunity.

AB - Immune memory is a defining feature of the acquired immune system, but activation of the innate immune system can also result in enhanced responsiveness to subsequent triggers. This process has been termed ‘trained immunity’, a de facto innate immune memory. Research in the past decade has pointed to the broad benefits of trained immunity for host defence but has also suggested potentially detrimental outcomes in immune-mediated and chronic inflammatory diseases. Here we define ‘trained immunity’ as a biological process and discuss the innate stimuli and the epigenetic and metabolic reprogramming events that shape the induction of trained immunity.

UR - https://www.scopus.com/pages/publications/85081372916

U2 - 10.1038/s41577-020-0285-6

DO - 10.1038/s41577-020-0285-6

M3 - Review article

C2 - 32132681

AN - SCOPUS:85081372916

SN - 1474-1733

VL - 20

SP - 375

EP - 388

JO - Nature Reviews Immunology

JF - Nature Reviews Immunology

IS - 6

ER -

Defining trained immunity and its role in health and disease

Abstract

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