Defining the Epithelial Stem Cell Niche in Skin

Tudorita Tumbar, Geraldine Guasch, Valentina Greco, Cedric Blanpain, William E. Lowry, Michael Rendl, Raine Fuchs

Research output: Contribution to journalArticlepeer-review

1682 Scopus citations


Many adult regenerative cells divide infrequently but have high proliferative capacity. We developed a strategy to fluorescently label slow-cycling cells in a cell type-specific fashion. We used this method to purify the label-retaining cells (LRCs) that mark the skin stem cell (SC) niche. We found that these cells rarely divide within their niche but change properties abruptly when stimulated to exit. We determined their transcriptional profile, which, when compared to progeny and other SCs, defines the niche. Many of the >100 messenger RNAs preferentially expressed in the niche encode surface receptors and secreted proteins, enabling LRCs to signal and respond to their environment.

Original languageEnglish
Pages (from-to)359-363
Number of pages5
Issue number5656
StatePublished - 16 Jan 2004
Externally publishedYes


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