Defining the chromatin landscape in demyelinating disorders

Jimmy Long Huynh; Patrizia Casaccia

doi:10.1016/j.nbd.2009.10.014

Defining the chromatin landscape in demyelinating disorders

Jimmy Long Huynh
, Patrizia Casaccia

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

An intricate network of epigenetic factors regulates cell differentiation by modulating the chromatin structure and ultimately affecting gene expression. This review describes the chromatin landscape defining oligodendrocyte progenitor differentiation during development and remyelination. We shall discuss the current knowledge regarding modifications of chromatin components during the progression of progenitors into myelinating cells and discuss the potential contribution of histone variants, microRNAs, and DNA methylation. We shall also briefly address how changes to this chromatin landscape can disturb this natural progression and alter the capacity to remyelinate.

Original language	English
Pages (from-to)	47-52
Number of pages	6
Journal	Neurobiology of Disease
Volume	39
Issue number	1
DOIs	https://doi.org/10.1016/j.nbd.2009.10.014
State	Published - Jul 2010
Externally published	Yes

Keywords

Demyelination
Epigenetics
Multiple sclerosis
Myelin
Oligodendrocyte differentiation

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10.1016/j.nbd.2009.10.014

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title = "Defining the chromatin landscape in demyelinating disorders",

abstract = "An intricate network of epigenetic factors regulates cell differentiation by modulating the chromatin structure and ultimately affecting gene expression. This review describes the chromatin landscape defining oligodendrocyte progenitor differentiation during development and remyelination. We shall discuss the current knowledge regarding modifications of chromatin components during the progression of progenitors into myelinating cells and discuss the potential contribution of histone variants, microRNAs, and DNA methylation. We shall also briefly address how changes to this chromatin landscape can disturb this natural progression and alter the capacity to remyelinate.",

keywords = "Demyelination, Epigenetics, Multiple sclerosis, Myelin, Oligodendrocyte differentiation",

author = "Huynh, \{Jimmy Long\} and Patrizia Casaccia",

note = "Funding Information: P.C. acknowledges the support of NIH-NINDS , grants RO1-NS42925 and RO1-NS52738 . J.L.H. was supported by a fellowship NIH T32 GM007280 and by the Foundation of the Consortium of Multiple Sclerosis Centers .",

year = "2010",

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T1 - Defining the chromatin landscape in demyelinating disorders

AU - Huynh, Jimmy Long

AU - Casaccia, Patrizia

N1 - Funding Information: P.C. acknowledges the support of NIH-NINDS , grants RO1-NS42925 and RO1-NS52738 . J.L.H. was supported by a fellowship NIH T32 GM007280 and by the Foundation of the Consortium of Multiple Sclerosis Centers .

PY - 2010/7

Y1 - 2010/7

N2 - An intricate network of epigenetic factors regulates cell differentiation by modulating the chromatin structure and ultimately affecting gene expression. This review describes the chromatin landscape defining oligodendrocyte progenitor differentiation during development and remyelination. We shall discuss the current knowledge regarding modifications of chromatin components during the progression of progenitors into myelinating cells and discuss the potential contribution of histone variants, microRNAs, and DNA methylation. We shall also briefly address how changes to this chromatin landscape can disturb this natural progression and alter the capacity to remyelinate.

AB - An intricate network of epigenetic factors regulates cell differentiation by modulating the chromatin structure and ultimately affecting gene expression. This review describes the chromatin landscape defining oligodendrocyte progenitor differentiation during development and remyelination. We shall discuss the current knowledge regarding modifications of chromatin components during the progression of progenitors into myelinating cells and discuss the potential contribution of histone variants, microRNAs, and DNA methylation. We shall also briefly address how changes to this chromatin landscape can disturb this natural progression and alter the capacity to remyelinate.

KW - Demyelination

KW - Epigenetics

KW - Multiple sclerosis

KW - Myelin

KW - Oligodendrocyte differentiation

UR - https://www.scopus.com/pages/publications/77952885093

U2 - 10.1016/j.nbd.2009.10.014

DO - 10.1016/j.nbd.2009.10.014

M3 - Review article

C2 - 19853663

AN - SCOPUS:77952885093

SN - 0969-9961

VL - 39

SP - 47

EP - 52

JO - Neurobiology of Disease

JF - Neurobiology of Disease

IS - 1

ER -

Defining the chromatin landscape in demyelinating disorders

Abstract

Keywords

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