@article{4afeef8a30a84c84b4537af2379e40a4,
title = "Defining genes: A computational framework",
abstract = "The precise elucidation of the gene concept has become the subject of intense discussion in light of results from several, large high-throughput surveys of transcriptomes and proteomes. In previous work, we proposed an approach for constructing gene concepts that combines genomic heritability with elements of function. Here, we introduce a definition of the gene within a computational framework of cellular interactions. The definition seeks to satisfy the practical requirements imposed by annotation, capture logical aspects of regulation, and encompass the evolutionary property of homology.",
keywords = "Computation, Gene concept, Homology, I/O-relations",
author = "Stadler, {Peter F.} and Prohaska, {Sonja J.} and Forst, {Christian V.} and Krakauer, {David C.}",
note = "Funding Information: Acknowledgments This work originated in the aftermath of the Workgroup on the Complexity of the Gene Concept, which took place at the Santa Fe Institute 8–11 March 2009 thanks to funding by the James S. McDonnel Foundation in Robustness. We are grateful for the intensive discussions on the topic with all the participants of this workshop. Sven Findei{\ss}{\textquoteright} comments on the manuscript are gratefully acknowledged. This work was funded in part by a grant from the Volkswagen Foundation on {\textquoteleft}{\textquoteleft}Evolution of networks: robustness, complexity and adaptability{\textquoteright}{\textquoteright} to PFS, and a grant on Innovation in Biological and Technological Systems from the David and Lucile Packard Foundation to DCK.",
year = "2009",
doi = "10.1007/s12064-009-0067-y",
language = "English",
volume = "128",
pages = "165--170",
journal = "Theory in Biosciences",
issn = "1431-7613",
publisher = "Springer Verlag",
number = "3 SPECIAL ISSUE",
}