Deep brain stimulation induces striatal dopamine release in obsessive-compulsive disorder

Martijn Figee; Pelle De Koning; Sanne Klaassen; Nienke Vulink; Mariska Mantione; Pepijn Van Den Munckhof; Richard Schuurman; Guido Van Wingen; Thérèse Van Amelsvoort; Jan Booij; Damiaan Denys

doi:10.1016/j.biopsych.2013.06.021

Deep brain stimulation induces striatal dopamine release in obsessive-compulsive disorder

Martijn Figee, Pelle De Koning, Sanne Klaassen, Nienke Vulink, Mariska Mantione, Pepijn Van Den Munckhof, Richard Schuurman, Guido Van Wingen, Thérèse Van Amelsvoort, Jan Booij, Damiaan Denys

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Abstract

Background Obsessive-compulsive disorder is a chronic psychiatric disorder related to dysfunctional dopaminergic neurotransmission. Deep brain stimulation (DBS) targeted at the nucleus accumbens (NAc) has recently become an effective treatment for therapy-refractory obsessive-compulsive disorder, but its effect on dopaminergic transmission is unknown. Methods We measured the effects of NAc DBS in 15 patients on the dopamine D_2/3 receptor availability in the striatum with [¹²³I]iodobenzamide ([¹²³I]IBZM) single photon emission computed tomography. We correlated changes in [ ¹²³I]IBZM binding potential (BP) with plasma levels of homovanillic acid (HVA) and clinical symptoms. Results Acute (1-hour) and chronic (1-year) DBS decreased striatal [¹²³I]IBZM BP compared with the nonstimulated condition in the putamen. BP decreases were observed after 1 hour of stimulation, and chronic stimulation was related to concurrent HVA plasma elevations, implying DBS-induced dopamine release. BP decreases in the area directly surrounding the electrodes were significantly correlated with changes in clinical symptoms (45% symptom decrease). Conclusions NAc DBS induced striatal dopamine release, which was associated with increased HVA plasma levels and improved clinical symptoms, suggesting that DBS may compensate for a defective dopaminergic system.

Original language	English
Pages (from-to)	647-652
Number of pages	6
Journal	Biological Psychiatry
Volume	75
Issue number	8
DOIs	https://doi.org/10.1016/j.biopsych.2013.06.021
State	Published - 15 Apr 2014
Externally published	Yes

Keywords

Deep brain stimulation
dopamine
homovanillic acid
neuroimaging
nucleus accumbens
obsessive-compulsive disorder

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10.1016/j.biopsych.2013.06.021

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@article{ada658fe844b4beebaa61c077a8900b6,

title = "Deep brain stimulation induces striatal dopamine release in obsessive-compulsive disorder",

abstract = "Background Obsessive-compulsive disorder is a chronic psychiatric disorder related to dysfunctional dopaminergic neurotransmission. Deep brain stimulation (DBS) targeted at the nucleus accumbens (NAc) has recently become an effective treatment for therapy-refractory obsessive-compulsive disorder, but its effect on dopaminergic transmission is unknown. Methods We measured the effects of NAc DBS in 15 patients on the dopamine D2/3 receptor availability in the striatum with [123I]iodobenzamide ([123I]IBZM) single photon emission computed tomography. We correlated changes in [ 123I]IBZM binding potential (BP) with plasma levels of homovanillic acid (HVA) and clinical symptoms. Results Acute (1-hour) and chronic (1-year) DBS decreased striatal [123I]IBZM BP compared with the nonstimulated condition in the putamen. BP decreases were observed after 1 hour of stimulation, and chronic stimulation was related to concurrent HVA plasma elevations, implying DBS-induced dopamine release. BP decreases in the area directly surrounding the electrodes were significantly correlated with changes in clinical symptoms (45% symptom decrease). Conclusions NAc DBS induced striatal dopamine release, which was associated with increased HVA plasma levels and improved clinical symptoms, suggesting that DBS may compensate for a defective dopaminergic system.",

keywords = "Deep brain stimulation, dopamine, homovanillic acid, neuroimaging, nucleus accumbens, obsessive-compulsive disorder",

author = "Martijn Figee and {De Koning}, Pelle and Sanne Klaassen and Nienke Vulink and Mariska Mantione and {Van Den Munckhof}, Pepijn and Richard Schuurman and {Van Wingen}, Guido and {Van Amelsvoort}, Th{\'e}r{\`e}se and Jan Booij and Damiaan Denys",

note = "Funding Information: Damiaan Denys receives occasional consultant fees from Medtronic for educational purposes. Richard Schuurman is an independent consultant for Medtronic Inc. on educational matters and received travel grants from the company. Pepijn van den Munckhof has received travel grants from Medtronic. All other authors report no biomedical financial interests or potential conflicts of interest.",

year = "2014",

month = apr,

day = "15",

doi = "10.1016/j.biopsych.2013.06.021",

language = "English",

volume = "75",

pages = "647--652",

journal = "Biological Psychiatry",

issn = "0006-3223",

publisher = "Elsevier USA",

number = "8",

}

TY - JOUR

T1 - Deep brain stimulation induces striatal dopamine release in obsessive-compulsive disorder

AU - Figee, Martijn

AU - De Koning, Pelle

AU - Klaassen, Sanne

AU - Vulink, Nienke

AU - Mantione, Mariska

AU - Van Den Munckhof, Pepijn

AU - Schuurman, Richard

AU - Van Wingen, Guido

AU - Van Amelsvoort, Thérèse

AU - Booij, Jan

AU - Denys, Damiaan

N1 - Funding Information: Damiaan Denys receives occasional consultant fees from Medtronic for educational purposes. Richard Schuurman is an independent consultant for Medtronic Inc. on educational matters and received travel grants from the company. Pepijn van den Munckhof has received travel grants from Medtronic. All other authors report no biomedical financial interests or potential conflicts of interest.

PY - 2014/4/15

Y1 - 2014/4/15

N2 - Background Obsessive-compulsive disorder is a chronic psychiatric disorder related to dysfunctional dopaminergic neurotransmission. Deep brain stimulation (DBS) targeted at the nucleus accumbens (NAc) has recently become an effective treatment for therapy-refractory obsessive-compulsive disorder, but its effect on dopaminergic transmission is unknown. Methods We measured the effects of NAc DBS in 15 patients on the dopamine D2/3 receptor availability in the striatum with [123I]iodobenzamide ([123I]IBZM) single photon emission computed tomography. We correlated changes in [ 123I]IBZM binding potential (BP) with plasma levels of homovanillic acid (HVA) and clinical symptoms. Results Acute (1-hour) and chronic (1-year) DBS decreased striatal [123I]IBZM BP compared with the nonstimulated condition in the putamen. BP decreases were observed after 1 hour of stimulation, and chronic stimulation was related to concurrent HVA plasma elevations, implying DBS-induced dopamine release. BP decreases in the area directly surrounding the electrodes were significantly correlated with changes in clinical symptoms (45% symptom decrease). Conclusions NAc DBS induced striatal dopamine release, which was associated with increased HVA plasma levels and improved clinical symptoms, suggesting that DBS may compensate for a defective dopaminergic system.

AB - Background Obsessive-compulsive disorder is a chronic psychiatric disorder related to dysfunctional dopaminergic neurotransmission. Deep brain stimulation (DBS) targeted at the nucleus accumbens (NAc) has recently become an effective treatment for therapy-refractory obsessive-compulsive disorder, but its effect on dopaminergic transmission is unknown. Methods We measured the effects of NAc DBS in 15 patients on the dopamine D2/3 receptor availability in the striatum with [123I]iodobenzamide ([123I]IBZM) single photon emission computed tomography. We correlated changes in [ 123I]IBZM binding potential (BP) with plasma levels of homovanillic acid (HVA) and clinical symptoms. Results Acute (1-hour) and chronic (1-year) DBS decreased striatal [123I]IBZM BP compared with the nonstimulated condition in the putamen. BP decreases were observed after 1 hour of stimulation, and chronic stimulation was related to concurrent HVA plasma elevations, implying DBS-induced dopamine release. BP decreases in the area directly surrounding the electrodes were significantly correlated with changes in clinical symptoms (45% symptom decrease). Conclusions NAc DBS induced striatal dopamine release, which was associated with increased HVA plasma levels and improved clinical symptoms, suggesting that DBS may compensate for a defective dopaminergic system.

KW - Deep brain stimulation

KW - dopamine

KW - homovanillic acid

KW - neuroimaging

KW - nucleus accumbens

KW - obsessive-compulsive disorder

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U2 - 10.1016/j.biopsych.2013.06.021

DO - 10.1016/j.biopsych.2013.06.021

M3 - Article

C2 - 23938318

AN - SCOPUS:84897108813

SN - 0006-3223

VL - 75

SP - 647

EP - 652

JO - Biological Psychiatry

JF - Biological Psychiatry

IS - 8

ER -

Deep brain stimulation induces striatal dopamine release in obsessive-compulsive disorder

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