Deep Brain Stimulation for Parkinson Disease

Fedor E. Panov, Andrew K.P. Conner, Paul Larson, Alastair Martin, Philip Starr

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Parkinson disease (PD) is the second most common neurodegenerative condition behind only Alzheimer disease and affects 1% of the population older than 65 years. This chapter provides an overview of the treatment of the motor abnormalities of PD using deep brain stimulation (DBS) via an physiologically guided approach and an MRI-guided approach. In addition, this chapter focuses on targeting the two most commonly used DBS targets in PD: the subthalamic nucleus and the pallidum. Finally, an update on the current understanding of the electrophysiologic basis of DBS is also thoroughly discussed.

Original languageEnglish
Title of host publicationYoumans and Winn Neurological Surgery
Subtitle of host publicationVolumes 1-4, 8th Edition
PublisherElsevier
Pages731-738.e2
ISBN (Electronic)9780323661928
ISBN (Print)9780323674997
DOIs
StatePublished - 1 Jan 2023
Externally publishedYes

Keywords

  • closed-loop stimulation
  • deep brain stimulation
  • globus pallidus
  • pallidum
  • Parkinson disease
  • stereotaxy
  • subthalamic nucleus
  • thalamus
  • ventral-intermediate nucleus

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