Abstract
Parkinson disease (PD) is the second most common neurodegenerative condition behind only Alzheimer disease and affects 1% of the population older than 65 years. This chapter provides an overview of the treatment of the motor abnormalities of PD using deep brain stimulation (DBS) via an physiologically guided approach and an MRI-guided approach. In addition, this chapter focuses on targeting the two most commonly used DBS targets in PD: the subthalamic nucleus and the pallidum. Finally, an update on the current understanding of the electrophysiologic basis of DBS is also thoroughly discussed.
Original language | English |
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Title of host publication | Youmans and Winn Neurological Surgery |
Subtitle of host publication | Volumes 1-4, 8th Edition |
Publisher | Elsevier |
Pages | 731-738.e2 |
ISBN (Electronic) | 9780323661928 |
ISBN (Print) | 9780323674997 |
DOIs | |
State | Published - 1 Jan 2023 |
Externally published | Yes |
Keywords
- closed-loop stimulation
- deep brain stimulation
- globus pallidus
- pallidum
- Parkinson disease
- stereotaxy
- subthalamic nucleus
- thalamus
- ventral-intermediate nucleus