Deep Brain Stimulation for Depression Informed by Intracranial Recordings

Sameer A. Sheth, Kelly R. Bijanki, Brian Metzger, Anusha Allawala, Victoria Pirtle, Joshua A. Adkinson, John Myers, Raissa K. Mathura, Denise Oswalt, Evangelia Tsolaki, Jiayang Xiao, Angela Noecker, Adriana M. Strutt, Jeffrey F. Cohn, Cameron C. McIntyre, Sanjay J. Mathew, David Borton, Wayne Goodman, Nader Pouratian

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


The success of deep brain stimulation (DBS) for treating Parkinson's disease has led to its application to several other disorders, including treatment-resistant depression. Results with DBS for treatment-resistant depression have been heterogeneous, with inconsistencies largely driven by incomplete understanding of the brain networks regulating mood, especially on an individual basis. We report results from the first subject treated with DBS for treatment-resistant depression using an approach that incorporates intracranial recordings to personalize understanding of network behavior and its response to stimulation. These recordings enabled calculation of individually optimized DBS stimulation parameters using a novel inverse solution approach. In the ensuing double-blind, randomized phase incorporating these bespoke parameter sets, DBS led to remission of symptoms and dramatic improvement in quality of life. Results from this initial case demonstrate the feasibility of this personalized platform, which may be used to improve surgical neuromodulation for a vast array of neurologic and psychiatric disorders.

Original languageEnglish
Pages (from-to)246-251
Number of pages6
JournalBiological Psychiatry
Issue number3
StatePublished - 1 Aug 2022
Externally publishedYes


  • Deep brain stimulation
  • Depression
  • Epilepsy
  • Network
  • Neuromodulation
  • Stereo-EEG


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