Dedifferentiation, Redifferentiation, and Transdifferentiation of Striated Muscles During Regeneration and Development

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

16 Scopus citations

Abstract

In some rare and striking cases, striated muscle fibers of the skeleton or body wall, which consist of terminally differentiated syncytia with complex ultrastructures, were found to be capable of dedifferentiating and fragmenting into mononucleate cells. Examples of such events will be discussed in which the dedifferentiated cells reenter the cell cycle, proliferate, and rebuilt damaged muscle fibers during limb regeneration or transdifferentiate to generate new types of muscles during normal development.

Original languageEnglish
Title of host publicationEssays on Developmental Biology, Part A, 2016
EditorsPaul M. Wassarman
PublisherAcademic Press Inc.
Pages331-355
Number of pages25
ISBN (Print)9780128029565
DOIs
StatePublished - 2016
Externally publishedYes

Publication series

NameCurrent Topics in Developmental Biology
Volume116
ISSN (Print)0070-2153

Keywords

  • Cell cycle reentry
  • Dedifferentiation
  • Heart muscles
  • Limb muscles
  • Muscle development
  • Muscle syncytia
  • Redifferentiation
  • Regeneration
  • Striated muscles
  • Transdifferentiation

Fingerprint

Dive into the research topics of 'Dedifferentiation, Redifferentiation, and Transdifferentiation of Striated Muscles During Regeneration and Development'. Together they form a unique fingerprint.

Cite this