Decreasing striatal 6-FDOPA uptake with increasing duration of cocaine withdrawal

Joseph C. Wu; Kate Bell; Ahmad Najafi; Cliff Widmark; Dave Keator; Cheuk Tang; Eric Klein; Blynn G. Bunney; James Fallon; William E. Bunney

doi:10.1016/S0893-133X(97)00089-4

Decreasing striatal 6-FDOPA uptake with increasing duration of cocaine withdrawal

Joseph C. Wu, Kate Bell, Ahmad Najafi, Cliff Widmark, Dave Keator, Cheuk Tang, Eric Klein, Blynn G. Bunney, James Fallon, William E. Bunney

BioMedical Engineering and Imaging Institute

Research output: Contribution to journal › Article › peer-review

84 Scopus citations

Abstract

It has been hypothesized that a decrease in dopaminergic presynaptic activity during abstinence or withdrawal is related to relapse in cocaine-dependent subjects (Dackis and Gold 1985; Markou and Koob 1991). This study measured striatal 6-fluorodopa (6-FDOPA) uptake, an index of dopaminergic presynaptic activity, using positron emission tomography (PET) in 11 drug-free cocaine addicts compared to eight normal subjects. Middle abstinence cocaine addicts (n = 5, off cocaine 11-30 days) had significantly lower striatal 6-FDOPA uptake compared to normal controls or early abstinence cocaine addicts (n = 6, off cocaine 1-10 days). The cocaine-dependent subjects (n 11) showed a significant negative correlation between days off cocaine and striatal 6-FDOPA uptake. The results suggest that during abstinence from cocaine there is a delayed decrease in dopamine terminal activity in the striatum.

Original language	English
Pages (from-to)	402-409
Number of pages	8
Journal	Neuropsychopharmacology
Volume	17
Issue number	6
DOIs	https://doi.org/10.1016/S0893-133X(97)00089-4
State	Published - Dec 1997

Keywords

Brain radionuclide imaging
Cocaine
Dopa analogs and derivatives
Dopamine metabolism
Emission computed tomography
Stimulants

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10.1016/S0893-133X(97)00089-4

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title = "Decreasing striatal 6-FDOPA uptake with increasing duration of cocaine withdrawal",

abstract = "It has been hypothesized that a decrease in dopaminergic presynaptic activity during abstinence or withdrawal is related to relapse in cocaine-dependent subjects (Dackis and Gold 1985; Markou and Koob 1991). This study measured striatal 6-fluorodopa (6-FDOPA) uptake, an index of dopaminergic presynaptic activity, using positron emission tomography (PET) in 11 drug-free cocaine addicts compared to eight normal subjects. Middle abstinence cocaine addicts (n = 5, off cocaine 11-30 days) had significantly lower striatal 6-FDOPA uptake compared to normal controls or early abstinence cocaine addicts (n = 6, off cocaine 1-10 days). The cocaine-dependent subjects (n 11) showed a significant negative correlation between days off cocaine and striatal 6-FDOPA uptake. The results suggest that during abstinence from cocaine there is a delayed decrease in dopamine terminal activity in the striatum.",

keywords = "Brain radionuclide imaging, Cocaine, Dopa analogs and derivatives, Dopamine metabolism, Emission computed tomography, Stimulants",

author = "Wu, {Joseph C.} and Kate Bell and Ahmad Najafi and Cliff Widmark and Dave Keator and Cheuk Tang and Eric Klein and Bunney, {Blynn G.} and James Fallon and Bunney, {William E.}",

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AU - Najafi, Ahmad

AU - Widmark, Cliff

AU - Keator, Dave

AU - Tang, Cheuk

AU - Klein, Eric

AU - Bunney, Blynn G.

AU - Fallon, James

AU - Bunney, William E.

PY - 1997/12

Y1 - 1997/12

N2 - It has been hypothesized that a decrease in dopaminergic presynaptic activity during abstinence or withdrawal is related to relapse in cocaine-dependent subjects (Dackis and Gold 1985; Markou and Koob 1991). This study measured striatal 6-fluorodopa (6-FDOPA) uptake, an index of dopaminergic presynaptic activity, using positron emission tomography (PET) in 11 drug-free cocaine addicts compared to eight normal subjects. Middle abstinence cocaine addicts (n = 5, off cocaine 11-30 days) had significantly lower striatal 6-FDOPA uptake compared to normal controls or early abstinence cocaine addicts (n = 6, off cocaine 1-10 days). The cocaine-dependent subjects (n 11) showed a significant negative correlation between days off cocaine and striatal 6-FDOPA uptake. The results suggest that during abstinence from cocaine there is a delayed decrease in dopamine terminal activity in the striatum.

AB - It has been hypothesized that a decrease in dopaminergic presynaptic activity during abstinence or withdrawal is related to relapse in cocaine-dependent subjects (Dackis and Gold 1985; Markou and Koob 1991). This study measured striatal 6-fluorodopa (6-FDOPA) uptake, an index of dopaminergic presynaptic activity, using positron emission tomography (PET) in 11 drug-free cocaine addicts compared to eight normal subjects. Middle abstinence cocaine addicts (n = 5, off cocaine 11-30 days) had significantly lower striatal 6-FDOPA uptake compared to normal controls or early abstinence cocaine addicts (n = 6, off cocaine 1-10 days). The cocaine-dependent subjects (n 11) showed a significant negative correlation between days off cocaine and striatal 6-FDOPA uptake. The results suggest that during abstinence from cocaine there is a delayed decrease in dopamine terminal activity in the striatum.

KW - Brain radionuclide imaging

KW - Cocaine

KW - Dopa analogs and derivatives

KW - Dopamine metabolism

KW - Emission computed tomography

KW - Stimulants

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Decreasing striatal 6-FDOPA uptake with increasing duration of cocaine withdrawal

Abstract

Keywords

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