Decreased umbilical cord serum ceruloplasmin concentrations in infants with hyaline membrane disease

J. A. Omene, A. C. Longe, J. C. Ihongbe, R. H. Glew, I. R. Holzman

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12 Scopus citations


Ceruloplasmin is a plasma copper metalloglycoprotein, synthesized by the liver and involved in the oxidation of ferrous iron to the ferric state and the transport of copper to peripheral tissues. A number of enzymes, including superoxide dismutase, contain copper. SOD also contains zinc and magnesium. The concentration of ceruloplasmin in serum is markedly age dependent and tends to parallel the concentration of copper. Cord blood from uncomplicated term deliveries contains a concentration of ceruloplasmin significantly below that of the adult and a similarly reduced copper concentration. The concentration of copper in premature infants tends to be low at birth and increases over the first 12 weeks of age. It has been postulated that there may be an association between a low ceruloplasmin concentration in premature infants and the concentration of copper. The studies of Gitlin and Biasucci suggest that a significant increase in ceruloplasmin concentration occurs after 26 weeks of gestation. During the course of pregnancy, the concentration of both ceruloplasmin and copper increases in maternal serum. During a recent survey of ceruloplasmin concentrations in Nigerian children with protein malnutrition, we analyzed serum from several infants with HMD. We found a profound deficiency of ceruloplasmin in cord blood specimens from infants with HMD.

Original languageEnglish
Pages (from-to)136-138
Number of pages3
JournalJournal of Pediatrics
Issue number1
StatePublished - 1981


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