Decreased striatal D2 receptor binding in non-manifesting carriers of the DYT1 dystonia mutation

K. Asanuma; Y. Ma; J. Okulski; V. Dhawan; T. Chaly; M. Carbon; S. B. Bressman; D. Eidelberg

doi:10.1212/01.WNL.0000149764.34953.BF

Decreased striatal D2 receptor binding in non-manifesting carriers of the DYT1 dystonia mutation

K. Asanuma, Y. Ma, J. Okulski, V. Dhawan, T. Chaly, M. Carbon, S. B. Bressman, D. Eidelberg

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137 Scopus citations

Abstract

To determine whether reduced striatal D₂ receptor binding reported in patients with idiopathic torsion dystonia is associated with the genotype, the authors used PET and [¹¹C]-raclopride to assess non-manifesting carriers of the DYT1 mutation. D₂ receptor binding was reduced by approximately 15% in caudate and putamen (p < 0.005). These results suggest that striatal D₂ binding reductions are a trait feature of the DYT1 genotype.

Original language	English
Pages (from-to)	347-349
Number of pages	3
Journal	Neurology
Volume	64
Issue number	2
DOIs	https://doi.org/10.1212/01.WNL.0000149764.34953.BF
State	Published - 25 Jan 2005
Externally published	Yes

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title = "Decreased striatal D2 receptor binding in non-manifesting carriers of the DYT1 dystonia mutation",

abstract = "To determine whether reduced striatal D2 receptor binding reported in patients with idiopathic torsion dystonia is associated with the genotype, the authors used PET and [11C]-raclopride to assess non-manifesting carriers of the DYT1 mutation. D2 receptor binding was reduced by approximately 15% in caudate and putamen (p < 0.005). These results suggest that striatal D2 binding reductions are a trait feature of the DYT1 genotype.",

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AU - Ma, Y.

AU - Okulski, J.

AU - Dhawan, V.

AU - Chaly, T.

AU - Carbon, M.

AU - Bressman, S. B.

AU - Eidelberg, D.

PY - 2005/1/25

Y1 - 2005/1/25

N2 - To determine whether reduced striatal D2 receptor binding reported in patients with idiopathic torsion dystonia is associated with the genotype, the authors used PET and [11C]-raclopride to assess non-manifesting carriers of the DYT1 mutation. D2 receptor binding was reduced by approximately 15% in caudate and putamen (p < 0.005). These results suggest that striatal D2 binding reductions are a trait feature of the DYT1 genotype.

AB - To determine whether reduced striatal D2 receptor binding reported in patients with idiopathic torsion dystonia is associated with the genotype, the authors used PET and [11C]-raclopride to assess non-manifesting carriers of the DYT1 mutation. D2 receptor binding was reduced by approximately 15% in caudate and putamen (p < 0.005). These results suggest that striatal D2 binding reductions are a trait feature of the DYT1 genotype.

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ER -

Decreased striatal D2 receptor binding in non-manifesting carriers of the DYT1 dystonia mutation

Abstract

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