Decreased expression of Ku70/Ku80 proteins in malignant melanomas of the oral cavity

Monika Korabiowska; Michael Tscherny; Ulrike Grohmann; Johannes F. Hönig; Stanislaw B. Bartkowski; Carlos Cordon-Cardo; Ulrich Brinck

Decreased expression of Ku70/Ku80 proteins in malignant melanomas of the oral cavity

Monika Korabiowska
, Michael Tscherny
, Ulrike Grohmann
, Johannes F. Hönig
, Stanislaw B. Bartkowski
, Carlos Cordon-Cardo
, Ulrich Brinck

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Ku70/80 are genes responsible for the repairing of DNA double-strand breaks and they function as a regulatory subunit of the DNA - dependent protein kinase. Their expression has not yet been investigated in malignant melanomas of the oral cavity. These tumours are characterized by very poor prognosis and etiology independent of UV-radiation. We investigated 29 malignant melanomas of the oral cavity for the expression of Ku70/80 proteins. Ku70 expression was preserved in 21 out of 29 tumours and the percentage of Ku70 - positive cells did not exceed 76%. Ku80 was found in 19 out of 29 tumours and the percentage of Ku80-positive cells peaked at 62%. Correlations between Ku70 and Ku80 expression were lost (p>0.05). We conclude that decreased Ku70/80 expression in malignant melanomas of the oral cavity and loss of correlation between these markers may influence progression of oral melanomas.

Original language	English
Pages (from-to)	193-196
Number of pages	4
Journal	Anticancer Research
Volume	22
Issue number	1 A
State	Published - 2002
Externally published	Yes

Keywords

Double-strand repair
Immunohistochemistry
Ku70
Ku80
Oral melanomas

Cite this

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title = "Decreased expression of Ku70/Ku80 proteins in malignant melanomas of the oral cavity",

abstract = "Ku70/80 are genes responsible for the repairing of DNA double-strand breaks and they function as a regulatory subunit of the DNA - dependent protein kinase. Their expression has not yet been investigated in malignant melanomas of the oral cavity. These tumours are characterized by very poor prognosis and etiology independent of UV-radiation. We investigated 29 malignant melanomas of the oral cavity for the expression of Ku70/80 proteins. Ku70 expression was preserved in 21 out of 29 tumours and the percentage of Ku70 - positive cells did not exceed 76\%. Ku80 was found in 19 out of 29 tumours and the percentage of Ku80-positive cells peaked at 62\%. Correlations between Ku70 and Ku80 expression were lost (p>0.05). We conclude that decreased Ku70/80 expression in malignant melanomas of the oral cavity and loss of correlation between these markers may influence progression of oral melanomas.",

keywords = "Double-strand repair, Immunohistochemistry, Ku70, Ku80, Oral melanomas",

author = "Monika Korabiowska and Michael Tscherny and Ulrike Grohmann and H{\"o}nig, \{Johannes F.\} and Bartkowski, \{Stanislaw B.\} and Carlos Cordon-Cardo and Ulrich Brinck",

year = "2002",

language = "English",

volume = "22",

pages = "193--196",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "1 A",

}

TY - JOUR

T1 - Decreased expression of Ku70/Ku80 proteins in malignant melanomas of the oral cavity

AU - Korabiowska, Monika

AU - Tscherny, Michael

AU - Grohmann, Ulrike

AU - Hönig, Johannes F.

AU - Bartkowski, Stanislaw B.

AU - Cordon-Cardo, Carlos

AU - Brinck, Ulrich

PY - 2002

Y1 - 2002

N2 - Ku70/80 are genes responsible for the repairing of DNA double-strand breaks and they function as a regulatory subunit of the DNA - dependent protein kinase. Their expression has not yet been investigated in malignant melanomas of the oral cavity. These tumours are characterized by very poor prognosis and etiology independent of UV-radiation. We investigated 29 malignant melanomas of the oral cavity for the expression of Ku70/80 proteins. Ku70 expression was preserved in 21 out of 29 tumours and the percentage of Ku70 - positive cells did not exceed 76%. Ku80 was found in 19 out of 29 tumours and the percentage of Ku80-positive cells peaked at 62%. Correlations between Ku70 and Ku80 expression were lost (p>0.05). We conclude that decreased Ku70/80 expression in malignant melanomas of the oral cavity and loss of correlation between these markers may influence progression of oral melanomas.

AB - Ku70/80 are genes responsible for the repairing of DNA double-strand breaks and they function as a regulatory subunit of the DNA - dependent protein kinase. Their expression has not yet been investigated in malignant melanomas of the oral cavity. These tumours are characterized by very poor prognosis and etiology independent of UV-radiation. We investigated 29 malignant melanomas of the oral cavity for the expression of Ku70/80 proteins. Ku70 expression was preserved in 21 out of 29 tumours and the percentage of Ku70 - positive cells did not exceed 76%. Ku80 was found in 19 out of 29 tumours and the percentage of Ku80-positive cells peaked at 62%. Correlations between Ku70 and Ku80 expression were lost (p>0.05). We conclude that decreased Ku70/80 expression in malignant melanomas of the oral cavity and loss of correlation between these markers may influence progression of oral melanomas.

KW - Double-strand repair

KW - Immunohistochemistry

KW - Ku70

KW - Ku80

KW - Oral melanomas

UR - https://www.scopus.com/pages/publications/0036244607

M3 - Article

C2 - 12017286

AN - SCOPUS:0036244607

SN - 0250-7005

VL - 22

SP - 193

EP - 196

JO - Anticancer Research

JF - Anticancer Research

IS - 1 A

ER -

Decreased expression of Ku70/Ku80 proteins in malignant melanomas of the oral cavity

Abstract

Keywords

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