Decoding simulated neurodynamics predicts the perceptual consequences of age-related macular degeneration

Jianing V. Shi, Jim Wielaard, R. Theodore Smith, Paul Sajda

Research output: Contribution to journalArticlepeer-review


Age-related macular degeneration (AMD) is the major cause of blindness in the developed world. Though substantial work has been done to characterize the disease, it is difficult to predict how the state of an individual's retina will ultimately affect their high-level perceptual function. In this paper, we describe an approach that couples retinal imaging with computational neural modeling of early visual processing to generate quantitative predictions of an individual's visual perception. Using a patient population with mild to moderate AMD, we show that we are able to accurately predict subject-specific psychometric performance by decoding simulated neurodynamics that are a function of scotomas derived from an individual's fundus image. On the population level, we find that our approach maps the disease on the retina to a representation that is a substantially better predictor of high-level perceptual performance than traditional clinical metrics such as drusen density and coverage. In summary, our work identifies possible new metrics for evaluating the efficacy of treatments for AMD at the level of the expected changes in high-level visual perception and, in general, typifies how computational neural models can be used as a framework to characterize the perceptual consequences of early visual pathologies.

Original languageEnglish
Pages (from-to)1-19
Number of pages19
JournalJournal of Vision
Issue number14
StatePublished - 2011
Externally publishedYes


  • Computational modeling
  • Low vision
  • Visual cortex


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