Deciphering signaling networks in osteosarcoma pathobiology

Christos Adamopoulos, Antonios N. Gargalionis, Efthimia K. Basdra, Athanasios G. Papavassiliou

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Osteosarcoma is the most frequent type of primary bone tumors among children and adolescents. During the past years, little progress has been made regarding prognosis of osteosarcoma patients, especially for those with metastatic disease. Genomic instability and gene alterations are common, but current data do not reveal a consistent and repeatable pattern of osteosarcoma development, thus paralleling the tumor's high heterogeneity. Critical signal transduction pathways have been implicated in osteosarcoma pathobiology and are being evaluated as therapeutic targets, including receptor activator for nuclear factor-κB (RANK), Wnt, Notch, phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin, and mechanotransduction pathways. Herein, we recapitulate and discuss recent advances in the context of molecular mechanisms and signaling networks that contribute to osteosarcoma progression and metastasis, towards patient-tailored and novel-targeted treatments.

Original languageEnglish
Pages (from-to)1296-1305
Number of pages10
JournalExperimental Biology and Medicine
Volume241
Issue number12
DOIs
StatePublished - 1 Jun 2016
Externally publishedYes

Keywords

  • Osteosarcoma
  • activator protein-1
  • mammalian target of rapamycin
  • mechanotransduction
  • nuclear factor-κB
  • signal transduction

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