Dear old dad.

Rivka L. Glaser, Ethylin Wang Jabs

Research output: Contribution to journalReview articlepeer-review

48 Scopus citations


The origin and frequency of spontaneous mutations that occur with age in humans have been a topic of intense discussion. The mechanisms by which spontaneous mutations arise depend on the parental germ line in which a mutation occurs. In general, paternal mutations are more likely than maternal mutations to be base substitutions. This is likely due to the larger number of germ cell divisions in spermatogenesis than in oogenesis. Maternal mutations are more often chromosomal abnormalities. Advanced parental age seems to influence some mutations, although it is not a factor in the creation of others. In this review, we focus on patterns of paternal bias and age dependence of mutations in different genetic disorders, and the various mechanisms by which these mutations arise. We also discuss recent data on age and the frequency of these mutations in the human male germ line and the impact of these data on this field of research.

Original languageEnglish
Pages (from-to)re1
JournalScience of aging knowledge environment : SAGE KE
Issue number3
StatePublished - 21 Jan 2004
Externally publishedYes


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