DCs and NK cells: Critical effectors in the immune response to HIV-1

Marcus Altfeld, Lena Fadda, Davor Frleta, Nina Bhardwaj

Research output: Contribution to journalReview articlepeer-review

156 Scopus citations

Abstract

Dendritic cells (DCs) and natural killer (NK) cells have central roles in antiviral immunity by shaping the quality of the adaptive immune response to viruses and by mediating direct antiviral activity. HIV-1 infection is characterized by a severe dysregulation of the antiviral immune response that starts during early infection. This Review describes recent insights into how HIV-1 infection affects DC and NK cell function, and the roles of these innate immune cells in HIV-1 pathogenesis. The importance of understanding DC and NK cell crosstalk during HIV infection for the development of effective antiviral strategies is also discussed.

Original languageEnglish
Pages (from-to)176-186
Number of pages11
JournalNature Reviews Immunology
Volume11
Issue number3
DOIs
StatePublished - Mar 2011
Externally publishedYes

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