DC-virus interplay: A double edged sword

Marie Larsson, Anne Sophie Beignon, Nina Bhardwaj

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations

Abstract

Myeloid and plasmacytoid dendritic cells, a family of professional antigen presenting cells, are crucial in generating and maintaining anti-viral immunity. Many viruses have evolved to avoid, subvert, and even counterattack them. In this article, we focus on the tuning of innate and adaptive responses induced by human dendritic cells, and on the inhibition of their functions by viruses of medical significance. A constant "tug of war" goes on between dendritic cells and viruses and a main dendritic cell countermeasure is cross-presentation/priming.

Original languageEnglish
Pages (from-to)147-161
Number of pages15
JournalSeminars in Immunology
Volume16
Issue number3
DOIs
StatePublished - Jun 2004
Externally publishedYes

Keywords

  • CMV
  • EBV
  • Epstein-Barr virus
  • HHV-6
  • HPV
  • HSV-1
  • HSV-2
  • LC
  • Langerhans cell
  • MDC
  • VZV
  • Varicella zoster virus
  • cytomegalovirus
  • herpes simplex virus-1
  • herpes simplex virus-2
  • human papilloma virus
  • myeloid dendritic cell
  • pDC
  • plasmacytoid dendritic cell

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