DC-virus interplay: A double edged sword

Marie Larsson; Anne Sophie Beignon; Nina Bhardwaj

doi:10.1016/j.smim.2004.02.002

DC-virus interplay: A double edged sword

Marie Larsson, Anne Sophie Beignon, Nina Bhardwaj

Research output: Contribution to journal › Review article › peer-review

46 Scopus citations

Abstract

Myeloid and plasmacytoid dendritic cells, a family of professional antigen presenting cells, are crucial in generating and maintaining anti-viral immunity. Many viruses have evolved to avoid, subvert, and even counterattack them. In this article, we focus on the tuning of innate and adaptive responses induced by human dendritic cells, and on the inhibition of their functions by viruses of medical significance. A constant "tug of war" goes on between dendritic cells and viruses and a main dendritic cell countermeasure is cross-presentation/priming.

Original language	English
Pages (from-to)	147-161
Number of pages	15
Journal	Seminars in Immunology
Volume	16
Issue number	3
DOIs	https://doi.org/10.1016/j.smim.2004.02.002
State	Published - Jun 2004
Externally published	Yes

Keywords

CMV
EBV
Epstein-Barr virus
HHV-6
HPV
HSV-1
HSV-2
LC
Langerhans cell
MDC
VZV
Varicella zoster virus
cytomegalovirus
herpes simplex virus-1
herpes simplex virus-2
human papilloma virus
myeloid dendritic cell
pDC
plasmacytoid dendritic cell

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10.1016/j.smim.2004.02.002

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title = "DC-virus interplay: A double edged sword",

abstract = "Myeloid and plasmacytoid dendritic cells, a family of professional antigen presenting cells, are crucial in generating and maintaining anti-viral immunity. Many viruses have evolved to avoid, subvert, and even counterattack them. In this article, we focus on the tuning of innate and adaptive responses induced by human dendritic cells, and on the inhibition of their functions by viruses of medical significance. A constant {"}tug of war{"} goes on between dendritic cells and viruses and a main dendritic cell countermeasure is cross-presentation/priming.",

keywords = "CMV, EBV, Epstein-Barr virus, HHV-6, HPV, HSV-1, HSV-2, LC, Langerhans cell, MDC, VZV, Varicella zoster virus, cytomegalovirus, herpes simplex virus-1, herpes simplex virus-2, human papilloma virus, myeloid dendritic cell, pDC, plasmacytoid dendritic cell",

author = "Marie Larsson and Beignon, {Anne Sophie} and Nina Bhardwaj",

note = "Funding Information: These studies were supported by grants to M. Larsson (FAIR award, NYU CFAR award) and to N. Bhardwaj (AI 44628, a Burroughs Wellcome Clinical Investigator Award, a Doris Duke Distinguished Clinical Scientist Award). N. Bhardwaj is an Elizabeth Glaser Scientist. ",

year = "2004",

month = jun,

doi = "10.1016/j.smim.2004.02.002",

language = "English",

volume = "16",

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journal = "Seminars in Immunology",

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TY - JOUR

T1 - DC-virus interplay

T2 - A double edged sword

AU - Larsson, Marie

AU - Beignon, Anne Sophie

AU - Bhardwaj, Nina

N1 - Funding Information: These studies were supported by grants to M. Larsson (FAIR award, NYU CFAR award) and to N. Bhardwaj (AI 44628, a Burroughs Wellcome Clinical Investigator Award, a Doris Duke Distinguished Clinical Scientist Award). N. Bhardwaj is an Elizabeth Glaser Scientist.

PY - 2004/6

Y1 - 2004/6

N2 - Myeloid and plasmacytoid dendritic cells, a family of professional antigen presenting cells, are crucial in generating and maintaining anti-viral immunity. Many viruses have evolved to avoid, subvert, and even counterattack them. In this article, we focus on the tuning of innate and adaptive responses induced by human dendritic cells, and on the inhibition of their functions by viruses of medical significance. A constant "tug of war" goes on between dendritic cells and viruses and a main dendritic cell countermeasure is cross-presentation/priming.

AB - Myeloid and plasmacytoid dendritic cells, a family of professional antigen presenting cells, are crucial in generating and maintaining anti-viral immunity. Many viruses have evolved to avoid, subvert, and even counterattack them. In this article, we focus on the tuning of innate and adaptive responses induced by human dendritic cells, and on the inhibition of their functions by viruses of medical significance. A constant "tug of war" goes on between dendritic cells and viruses and a main dendritic cell countermeasure is cross-presentation/priming.

KW - CMV

KW - EBV

KW - Epstein-Barr virus

KW - HHV-6

KW - HPV

KW - HSV-1

KW - HSV-2

KW - LC

KW - Langerhans cell

KW - MDC

KW - VZV

KW - Varicella zoster virus

KW - cytomegalovirus

KW - herpes simplex virus-1

KW - herpes simplex virus-2

KW - human papilloma virus

KW - myeloid dendritic cell

KW - pDC

KW - plasmacytoid dendritic cell

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U2 - 10.1016/j.smim.2004.02.002

DO - 10.1016/j.smim.2004.02.002

M3 - Review article

C2 - 15130499

AN - SCOPUS:2342481202

SN - 1044-5323

VL - 16

SP - 147

EP - 161

JO - Seminars in Immunology

JF - Seminars in Immunology

IS - 3

ER -

DC-virus interplay: A double edged sword

Abstract

Keywords

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