DAS SUBCHORIOIDAL IMPLANTIERTE GREENE-MELANOM: EIN TIEREXPERIMENTELLES MODELL FUR DAS MALIGNE ADERHAUTMELANOM

K. G. Riedel; P. P. Svitra; D. M. Albert; P. T. Finger; S. Packer

doi:10.1055/s-2008-1046255

DAS SUBCHORIOIDAL IMPLANTIERTE GREENE-MELANOM: EIN TIEREXPERIMENTELLES MODELL FUR DAS MALIGNE ADERHAUTMELANOM

Translated title of the contribution: Choroidal Greene melanoma: An experimental model for human choroidal melanoma

K. G. Riedel, P. P. Svitra, D. M. Albert, P. T. Finger, S. Packer

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A modified technique for subchoroidal transplantation of amelanotic Greene melanoma cells and the intraocular growth patterns of this tumor in rabbit eyes are described. Tumor fragments were implanted via a scleral tunnel in 71 rabbit eyes, with 64 successful tumor growths, producing a prominent, circumscribed choroidal mass within 12-14 days of surgery. Choroidal Greene melanoma in rabbits resembles human epitheloid uveal melanoma in both its growth patterns and morphologic characteristics. The authors' implantation technique guarantees reliable growth of choroidal tumors with easily reproducible size and location. The experimental choroidal melanoma model is particularly valuable in clinical studies where a large number of tumors, with limited variation, is necessary for different experimental groups.

Translated title of the contribution	Choroidal Greene melanoma: An experimental model for human choroidal melanoma
Original language	German
Pages (from-to)	128-132
Number of pages	5
Journal	Klinische Monatsblatter fur Augenheilkunde
Volume	197
Issue number	2
DOIs	https://doi.org/10.1055/s-2008-1046255
State	Published - 1990
Externally published	Yes

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title = "DAS SUBCHORIOIDAL IMPLANTIERTE GREENE-MELANOM: EIN TIEREXPERIMENTELLES MODELL FUR DAS MALIGNE ADERHAUTMELANOM",

abstract = "A modified technique for subchoroidal transplantation of amelanotic Greene melanoma cells and the intraocular growth patterns of this tumor in rabbit eyes are described. Tumor fragments were implanted via a scleral tunnel in 71 rabbit eyes, with 64 successful tumor growths, producing a prominent, circumscribed choroidal mass within 12-14 days of surgery. Choroidal Greene melanoma in rabbits resembles human epitheloid uveal melanoma in both its growth patterns and morphologic characteristics. The authors' implantation technique guarantees reliable growth of choroidal tumors with easily reproducible size and location. The experimental choroidal melanoma model is particularly valuable in clinical studies where a large number of tumors, with limited variation, is necessary for different experimental groups.",

author = "Riedel, {K. G.} and Svitra, {P. P.} and Albert, {D. M.} and Finger, {P. T.} and S. Packer",

year = "1990",

doi = "10.1055/s-2008-1046255",

language = "German",

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pages = "128--132",

journal = "Klinische Monatsblatter fur Augenheilkunde",

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T2 - EIN TIEREXPERIMENTELLES MODELL FUR DAS MALIGNE ADERHAUTMELANOM

AU - Riedel, K. G.

AU - Svitra, P. P.

AU - Albert, D. M.

AU - Finger, P. T.

AU - Packer, S.

PY - 1990

Y1 - 1990

N2 - A modified technique for subchoroidal transplantation of amelanotic Greene melanoma cells and the intraocular growth patterns of this tumor in rabbit eyes are described. Tumor fragments were implanted via a scleral tunnel in 71 rabbit eyes, with 64 successful tumor growths, producing a prominent, circumscribed choroidal mass within 12-14 days of surgery. Choroidal Greene melanoma in rabbits resembles human epitheloid uveal melanoma in both its growth patterns and morphologic characteristics. The authors' implantation technique guarantees reliable growth of choroidal tumors with easily reproducible size and location. The experimental choroidal melanoma model is particularly valuable in clinical studies where a large number of tumors, with limited variation, is necessary for different experimental groups.

AB - A modified technique for subchoroidal transplantation of amelanotic Greene melanoma cells and the intraocular growth patterns of this tumor in rabbit eyes are described. Tumor fragments were implanted via a scleral tunnel in 71 rabbit eyes, with 64 successful tumor growths, producing a prominent, circumscribed choroidal mass within 12-14 days of surgery. Choroidal Greene melanoma in rabbits resembles human epitheloid uveal melanoma in both its growth patterns and morphologic characteristics. The authors' implantation technique guarantees reliable growth of choroidal tumors with easily reproducible size and location. The experimental choroidal melanoma model is particularly valuable in clinical studies where a large number of tumors, with limited variation, is necessary for different experimental groups.

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JF - Klinische Monatsblatter fur Augenheilkunde

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DAS SUBCHORIOIDAL IMPLANTIERTE GREENE-MELANOM: EIN TIEREXPERIMENTELLES MODELL FUR DAS MALIGNE ADERHAUTMELANOM

Abstract

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