Darm-Leber-Achse – wie der Darm die Leber krank macht

Translated title of the contribution: The gut–liver axis: how the gut promotes liver disease

Münevver Demir, Frank Tacke

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Research over the last two decades has highlighted the major role played by the gut microbiota in health and disease, including chronic liver diseases. The liver and intestine communicate via the portal vein, biliary system, and mediators in the circulation (gut–liver axis). Microbes in the intestine are involved in the maintenance of liver homeostasis. Conversely, alterations in the normal composition or diversity of the gut microbiome—a condition called dysbiosis—can also serve as a source of pathogens and molecules that contribute to the onset or progression of chronic liver diseases, like non-alcoholic fatty liver disease. Through the increased production of bacteria-derived ethanol, altered bile acid metabolism, altered production of short-chain fatty acids, greater abundance of lipopolysaccharide (LPS) containing Gram-negative bacteria and an increased intestinal permeability, dysbiosis impacts metabolic pathways and inflammatory processes. However, the clinical relevance of specific gut microbial alterations associated with chronic liver diseases remains unclear. This review discusses how microbes and their products contribute to liver disease pathogenesis and how targeting the microbiota might be used for therapeutic approaches.

Translated title of the contributionThe gut–liver axis: how the gut promotes liver disease
Original languageGerman
Pages (from-to)1028-1035
Number of pages8
JournalInnere Medizin (Germany)
Volume63
Issue number10
DOIs
StatePublished - Oct 2022
Externally publishedYes

Keywords

  • Bile acids
  • Gut microbiome
  • Gut microbiota
  • Non-alcoholic fatty liver disease
  • Short-chain fatty acids

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