@article{673515a93ca542daa4dff6c90da50bae,
title = "Dark genome, bright ideas: Recent approaches to harness transposable elements in immunotherapies",
abstract = "Transposable elements (TEs), which make up almost half of the human genome, often display altered expression in cancers. Here, we review recent progress in elucidating the role of TEs as mediators of immune responses in cancer and discuss how novel therapeutic strategies can harness TE immunogenicity for cancer immunotherapy.",
author = "{Reid Cahn}, Ashley and Nina Bhardwaj and Nicolas Vabret",
note = "Funding Information: N.B. has received honoraria for speaking engagements from Pfizer and research funds from the Cancer Research Institute, Merck, Regeneron, Ludwig Institute, Melanoma Research Alliance, Leukemia & Lymphoma Society, and Antidote Health Foundation and reports consultancy and/or advisory roles for Novartis, Apricity, Rome Therapeutics, CureVac, Genotwin, BioNTech, Gilead, Tempest Therapeutics, Genentech , and Rubis Therapeutics. N.V. acknowledges funding from Melanoma Research Foundation for this work. A.R.C. declares no competing interests. Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",
year = "2022",
month = aug,
day = "8",
doi = "10.1016/j.ccell.2022.07.003",
language = "English",
volume = "40",
pages = "792--797",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "8",
}