Dark genome, bright ideas: Recent approaches to harness transposable elements in immunotherapies

Ashley Reid Cahn; Nina Bhardwaj; Nicolas Vabret

doi:10.1016/j.ccell.2022.07.003

Dark genome, bright ideas: Recent approaches to harness transposable elements in immunotherapies

Ashley Reid Cahn, Nina Bhardwaj, Nicolas Vabret

Research output: Contribution to journal › Comment/debate

13 Scopus citations

Abstract

Transposable elements (TEs), which make up almost half of the human genome, often display altered expression in cancers. Here, we review recent progress in elucidating the role of TEs as mediators of immune responses in cancer and discuss how novel therapeutic strategies can harness TE immunogenicity for cancer immunotherapy.

Original language	English
Pages (from-to)	792-797
Number of pages	6
Journal	Cancer Cell
Volume	40
Issue number	8
DOIs	https://doi.org/10.1016/j.ccell.2022.07.003
State	Published - 8 Aug 2022

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@article{673515a93ca542daa4dff6c90da50bae,

title = "Dark genome, bright ideas: Recent approaches to harness transposable elements in immunotherapies",

abstract = "Transposable elements (TEs), which make up almost half of the human genome, often display altered expression in cancers. Here, we review recent progress in elucidating the role of TEs as mediators of immune responses in cancer and discuss how novel therapeutic strategies can harness TE immunogenicity for cancer immunotherapy.",

author = "{Reid Cahn}, Ashley and Nina Bhardwaj and Nicolas Vabret",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",

year = "2022",

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T2 - Recent approaches to harness transposable elements in immunotherapies

AU - Reid Cahn, Ashley

AU - Bhardwaj, Nina

AU - Vabret, Nicolas

PY - 2022/8/8

Y1 - 2022/8/8

N2 - Transposable elements (TEs), which make up almost half of the human genome, often display altered expression in cancers. Here, we review recent progress in elucidating the role of TEs as mediators of immune responses in cancer and discuss how novel therapeutic strategies can harness TE immunogenicity for cancer immunotherapy.

AB - Transposable elements (TEs), which make up almost half of the human genome, often display altered expression in cancers. Here, we review recent progress in elucidating the role of TEs as mediators of immune responses in cancer and discuss how novel therapeutic strategies can harness TE immunogenicity for cancer immunotherapy.

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U2 - 10.1016/j.ccell.2022.07.003

DO - 10.1016/j.ccell.2022.07.003

M3 - Comment/debate

AN - SCOPUS:85135142048

SN - 1535-6108

VL - 40

SP - 792

EP - 797

JO - Cancer Cell

JF - Cancer Cell

IS - 8

ER -

Dark genome, bright ideas: Recent approaches to harness transposable elements in immunotherapies

Abstract

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