Dangerous Liaisons: Deviant Endothelium NOTCHes toward Tumor Metastasis

Peipei Guo, Shahin Rafii

Research output: Contribution to journalShort surveypeer-review

3 Scopus citations


In this issue of Cancer Cell, Wieland et al. uncover a feedback loop in which tumor cells, by augmenting Notch signaling, provoke a senescent and pro-inflammatory state in endothelial cells, promoting neutrophil infiltration, tumor cell adhesion, and metastasis. Interfering with this Notch-dependent crosstalk may be a therapeutic approach to block metastasis.

Original languageEnglish
Pages (from-to)301-303
Number of pages3
JournalCancer Cell
Issue number3
StatePublished - 13 Mar 2017
Externally publishedYes


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