Dangerous Liaisons: Deviant Endothelium NOTCHes toward Tumor Metastasis

Peipei Guo; Shahin Rafii

doi:10.1016/j.ccell.2017.02.016

Dangerous Liaisons: Deviant Endothelium NOTCHes toward Tumor Metastasis

Peipei Guo, Shahin Rafii

Research output: Contribution to journal › Short survey › peer-review

3 Scopus citations

Abstract

In this issue of Cancer Cell, Wieland et al. uncover a feedback loop in which tumor cells, by augmenting Notch signaling, provoke a senescent and pro-inflammatory state in endothelial cells, promoting neutrophil infiltration, tumor cell adhesion, and metastasis. Interfering with this Notch-dependent crosstalk may be a therapeutic approach to block metastasis.

Original language	English
Pages (from-to)	301-303
Number of pages	3
Journal	Cancer Cell
Volume	31
Issue number	3
DOIs	https://doi.org/10.1016/j.ccell.2017.02.016
State	Published - 13 Mar 2017
Externally published	Yes

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@article{295ae65ebebd4da587dddd5aac0af04b,

title = "Dangerous Liaisons: Deviant Endothelium NOTCHes toward Tumor Metastasis",

abstract = "In this issue of Cancer Cell, Wieland et al. uncover a feedback loop in which tumor cells, by augmenting Notch signaling, provoke a senescent and pro-inflammatory state in endothelial cells, promoting neutrophil infiltration, tumor cell adhesion, and metastasis. Interfering with this Notch-dependent crosstalk may be a therapeutic approach to block metastasis.",

author = "Peipei Guo and Shahin Rafii",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",

year = "2017",

month = mar,

day = "13",

doi = "10.1016/j.ccell.2017.02.016",

language = "English",

volume = "31",

pages = "301--303",

journal = "Cancer Cell",

issn = "1535-6108",

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number = "3",

}

TY - JOUR

T1 - Dangerous Liaisons

T2 - Deviant Endothelium NOTCHes toward Tumor Metastasis

AU - Guo, Peipei

AU - Rafii, Shahin

PY - 2017/3/13

Y1 - 2017/3/13

N2 - In this issue of Cancer Cell, Wieland et al. uncover a feedback loop in which tumor cells, by augmenting Notch signaling, provoke a senescent and pro-inflammatory state in endothelial cells, promoting neutrophil infiltration, tumor cell adhesion, and metastasis. Interfering with this Notch-dependent crosstalk may be a therapeutic approach to block metastasis.

AB - In this issue of Cancer Cell, Wieland et al. uncover a feedback loop in which tumor cells, by augmenting Notch signaling, provoke a senescent and pro-inflammatory state in endothelial cells, promoting neutrophil infiltration, tumor cell adhesion, and metastasis. Interfering with this Notch-dependent crosstalk may be a therapeutic approach to block metastasis.

UR - http://www.scopus.com/inward/record.url?scp=85015010568&partnerID=8YFLogxK

U2 - 10.1016/j.ccell.2017.02.016

DO - 10.1016/j.ccell.2017.02.016

M3 - Short survey

C2 - 28292430

AN - SCOPUS:85015010568

SN - 1535-6108

VL - 31

SP - 301

EP - 303

JO - Cancer Cell

JF - Cancer Cell

IS - 3

ER -

Dangerous Liaisons: Deviant Endothelium NOTCHes toward Tumor Metastasis

Abstract

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