Daily production and metabolic clearance of growth hormone in juvenile diabetes mellitus

M. A. Sperling, F. Wollesen, P. V. DeLamater

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39 Scopus citations


Daily production (PR) of human growth hormone (HGH) was calculated in patients with juvenile diabetes and control subjects by determining metabolic clearance rate (MCR) of131I HGH, at equilibrium, and mean endogenous HGH levels throughout a 24 h day. Half hourly sampling or a constant withdrawal pump were used to obtain an integrated mean endogenous HGH level. MCR (liters/day) was significantly reduced in all diabetic subjects both in absolute terms (96 ± 15 vs 274 ± 37) and relative to surface area (62 ± 8 vs 171 ± 21) (p < 0.01). Mean HGH levels were 8.4 ng/ml in the diabetics and 5.5 ng/ml in age matched controls. Daily HGH PR in the diabetic subjects (339 to 1365 μg/day) did not exceed values in the control subjects (1005-1426 μg/day). The results indicate that the elevated plasma HGH levels and increased HGH response to stimuli observed in diabetes, reflect reduced metabolic clearance, rather than increased pituitary secretion.

Original languageEnglish
Pages (from-to)380-383
Number of pages4
Issue number5
StatePublished - Oct 1973
Externally publishedYes


  • Growth Hormone
  • daily production
  • integrated mean levels
  • juvenile diabetes
  • metabolic clearance


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