Da qing, finnish DPP, tripod, and dream: Lifestyle and thiazolidinediones in the prevention of diabetes

Nearly one in seven adults in the United States has diabetes-but more than twice that number are at risk of diabetes, based on impaired glucose tolerance (IGT, 2-h glucose >140 and >200 mg/dL) or impaired fasting glucose (IFG, fasting glucose 100 and 126 mg/dL) based on an oral glucose tolerance test (OGTT) [ 1 ]. In the world, the prevalence of these diabetes risk states exceeds 8% of the adult population [ 2 ]. Given the high complication rates of diabetes, a great deal of interest has focused on measures to reduce the progression of this risk state. We review the results of two studies of lifestyle modi fi cation and two studies of thiazolidinedione administration in the prevention of diabetes.