d-Penicillamine-induced neuromuscular disease in guinea pigs

John H. McVicker; Neil S. Lava; Thomas W. Mittag; Steven P. Ringel

doi:10.1016/0014-4886(82)90100-5

d-Penicillamine-induced neuromuscular disease in guinea pigs

John H. McVicker
, Neil S. Lava
, Thomas W. Mittag
, Steven P. Ringel

Icahn School of Medicine at Mount Sinai

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

We found that chronic d-penicillamine administration in guinea pigs may induce a variety of electrophysiologic, histologic, and serologic changes that are reminiscent of features of both experimental allergic myositis and experimental allergic myasthenia gravis. These include (i) electromyographic decrement following repetitive stimulation that is reversible with edrophonium, and augmentation of twitch tension with edrophonium; (ii) nonspecific inflammatory and necrotic changes in muscle; and (iii) significant elevation of acetylcholine receptor antibody. The guinea-pig model raises several questions that must be answered before it can be regarded as a reliable model of d-penicillamine-induced neuromuscular disease in humans.

Original language	English
Pages (from-to)	46-57
Number of pages	12
Journal	Experimental Neurology
Volume	76
Issue number	1
DOIs	https://doi.org/10.1016/0014-4886(82)90100-5
State	Published - Apr 1982

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@article{618e6c7667be43989b62febc870d6ac1,

title = "d-Penicillamine-induced neuromuscular disease in guinea pigs",

abstract = "We found that chronic d-penicillamine administration in guinea pigs may induce a variety of electrophysiologic, histologic, and serologic changes that are reminiscent of features of both experimental allergic myositis and experimental allergic myasthenia gravis. These include (i) electromyographic decrement following repetitive stimulation that is reversible with edrophonium, and augmentation of twitch tension with edrophonium; (ii) nonspecific inflammatory and necrotic changes in muscle; and (iii) significant elevation of acetylcholine receptor antibody. The guinea-pig model raises several questions that must be answered before it can be regarded as a reliable model of d-penicillamine-induced neuromuscular disease in humans.",

author = "McVicker, \{John H.\} and Lava, \{Neil S.\} and Mittag, \{Thomas W.\} and Ringel, \{Steven P.\}",

note = "Funding Information: Abbreviations: DP-D-Penicillamine, EMG-electromyogram, receptor antibody, a-BuTx-cu-bungarotoxin, GI-gastrointestinal. {\textquoteright} This study was sponsored in part through a grant from the Colorado Chapter of the Myasthenia Gravis Foundation and the Muscular Dystrophy Association (Dr. Lava) and National Institutes of Health grant NS-IO1 24 (Dr. Mittag). This work was presented at the 31st Meeting, American Academy of Neurology, April 26, 1979, Chicago, Illinois. Correspondence and reprint requests should be addressed to Dr. S. P. Ringel, Department of Neurology, B185, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262. We would like to thank Merck, Sharp, and Dohme, West Point, Pennsylvania, who generously supplied the cupramine (D-pCniCik3miIIe) and Dr. Cathy Craven who assisted in the interpretation of the thymus histology.",

year = "1982",

month = apr,

doi = "10.1016/0014-4886(82)90100-5",

language = "English",

volume = "76",

pages = "46--57",

journal = "Experimental Neurology",

issn = "0014-4886",

publisher = "Academic Press Inc.",

number = "1",

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T1 - d-Penicillamine-induced neuromuscular disease in guinea pigs

AU - McVicker, John H.

AU - Lava, Neil S.

AU - Mittag, Thomas W.

AU - Ringel, Steven P.

N1 - Funding Information: Abbreviations: DP-D-Penicillamine, EMG-electromyogram, receptor antibody, a-BuTx-cu-bungarotoxin, GI-gastrointestinal. ’ This study was sponsored in part through a grant from the Colorado Chapter of the Myasthenia Gravis Foundation and the Muscular Dystrophy Association (Dr. Lava) and National Institutes of Health grant NS-IO1 24 (Dr. Mittag). This work was presented at the 31st Meeting, American Academy of Neurology, April 26, 1979, Chicago, Illinois. Correspondence and reprint requests should be addressed to Dr. S. P. Ringel, Department of Neurology, B185, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262. We would like to thank Merck, Sharp, and Dohme, West Point, Pennsylvania, who generously supplied the cupramine (D-pCniCik3miIIe) and Dr. Cathy Craven who assisted in the interpretation of the thymus histology.

PY - 1982/4

Y1 - 1982/4

N2 - We found that chronic d-penicillamine administration in guinea pigs may induce a variety of electrophysiologic, histologic, and serologic changes that are reminiscent of features of both experimental allergic myositis and experimental allergic myasthenia gravis. These include (i) electromyographic decrement following repetitive stimulation that is reversible with edrophonium, and augmentation of twitch tension with edrophonium; (ii) nonspecific inflammatory and necrotic changes in muscle; and (iii) significant elevation of acetylcholine receptor antibody. The guinea-pig model raises several questions that must be answered before it can be regarded as a reliable model of d-penicillamine-induced neuromuscular disease in humans.

AB - We found that chronic d-penicillamine administration in guinea pigs may induce a variety of electrophysiologic, histologic, and serologic changes that are reminiscent of features of both experimental allergic myositis and experimental allergic myasthenia gravis. These include (i) electromyographic decrement following repetitive stimulation that is reversible with edrophonium, and augmentation of twitch tension with edrophonium; (ii) nonspecific inflammatory and necrotic changes in muscle; and (iii) significant elevation of acetylcholine receptor antibody. The guinea-pig model raises several questions that must be answered before it can be regarded as a reliable model of d-penicillamine-induced neuromuscular disease in humans.

UR - https://www.scopus.com/pages/publications/0020040495

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DO - 10.1016/0014-4886(82)90100-5

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C2 - 7084364

AN - SCOPUS:0020040495

SN - 0014-4886

VL - 76

SP - 46

EP - 57

JO - Experimental Neurology

JF - Experimental Neurology

IS - 1

ER -

d-Penicillamine-induced neuromuscular disease in guinea pigs

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