D-cycloserine, a novel cognitive enhancer, improves spatial memory in aged rats

Mark G. Baxter; Thomas H. Lanthorn; Karyn M. Frick; Stephanie Golski; Rui Qian Wan; David S. Olton

doi:10.1016/0197-4580(94)90114-7

D-cycloserine, a novel cognitive enhancer, improves spatial memory in aged rats

Mark G. Baxter, Thomas H. Lanthorn, Karyn M. Frick, Stephanie Golski, Rui Qian Wan, David S. Olton

Research output: Contribution to journal › Article › peer-review

124 Scopus citations

Abstract

D-cycloserine, a partial agonist of the NMDA receptor-associated glycine site, can enhance cognition. The present experiment examines the behavioral effects of D-cycloserine on cognitive deficits in male Fischer-344 rats, 24 months old. Rats 24 months old (n = 42) received either vehicle or one of 3 doses of D-cycloserine prior to testing. Young rats, 4 months old (n = 13), received vehicle prior to testing. Place discrimination and repeated acquisition were tested in the water maze and a variety of sensorimotor tasks were given. Aging impaired performance in all tasks. D-cycloserine improved performance in place discrimination and repeated acquisition. No doses affected sensorimotor function. These results support the hypothesis that D-cycloserine has cognition enhancing properties and that it may be useful in treating disorders involving cognitive impairment.

Original language	English
Pages (from-to)	207-213
Number of pages	7
Journal	Neurobiology of Aging
Volume	15
Issue number	2
DOIs	https://doi.org/10.1016/0197-4580(94)90114-7
State	Published - 1994
Externally published	Yes

Keywords

Aging
Cognitive enhancer
D-Cycloserine
Fischer-344 rats
Glycine partial agonist
Spatial memory

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10.1016/0197-4580(94)90114-7

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title = "D-cycloserine, a novel cognitive enhancer, improves spatial memory in aged rats",

abstract = "D-cycloserine, a partial agonist of the NMDA receptor-associated glycine site, can enhance cognition. The present experiment examines the behavioral effects of D-cycloserine on cognitive deficits in male Fischer-344 rats, 24 months old. Rats 24 months old (n = 42) received either vehicle or one of 3 doses of D-cycloserine prior to testing. Young rats, 4 months old (n = 13), received vehicle prior to testing. Place discrimination and repeated acquisition were tested in the water maze and a variety of sensorimotor tasks were given. Aging impaired performance in all tasks. D-cycloserine improved performance in place discrimination and repeated acquisition. No doses affected sensorimotor function. These results support the hypothesis that D-cycloserine has cognition enhancing properties and that it may be useful in treating disorders involving cognitive impairment.",

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AU - Baxter, Mark G.

AU - Lanthorn, Thomas H.

AU - Frick, Karyn M.

AU - Golski, Stephanie

AU - Wan, Rui Qian

AU - Olton, David S.

PY - 1994

Y1 - 1994

N2 - D-cycloserine, a partial agonist of the NMDA receptor-associated glycine site, can enhance cognition. The present experiment examines the behavioral effects of D-cycloserine on cognitive deficits in male Fischer-344 rats, 24 months old. Rats 24 months old (n = 42) received either vehicle or one of 3 doses of D-cycloserine prior to testing. Young rats, 4 months old (n = 13), received vehicle prior to testing. Place discrimination and repeated acquisition were tested in the water maze and a variety of sensorimotor tasks were given. Aging impaired performance in all tasks. D-cycloserine improved performance in place discrimination and repeated acquisition. No doses affected sensorimotor function. These results support the hypothesis that D-cycloserine has cognition enhancing properties and that it may be useful in treating disorders involving cognitive impairment.

AB - D-cycloserine, a partial agonist of the NMDA receptor-associated glycine site, can enhance cognition. The present experiment examines the behavioral effects of D-cycloserine on cognitive deficits in male Fischer-344 rats, 24 months old. Rats 24 months old (n = 42) received either vehicle or one of 3 doses of D-cycloserine prior to testing. Young rats, 4 months old (n = 13), received vehicle prior to testing. Place discrimination and repeated acquisition were tested in the water maze and a variety of sensorimotor tasks were given. Aging impaired performance in all tasks. D-cycloserine improved performance in place discrimination and repeated acquisition. No doses affected sensorimotor function. These results support the hypothesis that D-cycloserine has cognition enhancing properties and that it may be useful in treating disorders involving cognitive impairment.

KW - Aging

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KW - D-Cycloserine

KW - Fischer-344 rats

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D-cycloserine, a novel cognitive enhancer, improves spatial memory in aged rats

Abstract

Keywords

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