D-amphetamine challenge effects on Wisconsin Card Sort Test. Performance in schizotypal personality disorder

Benjamin V. Siegel; Robert L. Trestman; Séamus O'Flaithbheartaigh; Vivian Mitropoulou; Farooq Amin; Richelle Kirrane; Jeremy Silverman; James Schmeidler; Richard S.E. Keefe; Larry J. Siever

doi:10.1016/0920-9964(95)00002-X

D-amphetamine challenge effects on Wisconsin Card Sort Test. Performance in schizotypal personality disorder

Benjamin V. Siegel
, Robert L. Trestman
, Séamus O'Flaithbheartaigh
, Vivian Mitropoulou
, Farooq Amin
, Richelle Kirrane
, Jeremy Silverman
, James Schmeidler
, Richard S.E. Keefe
, Larry J. Siever

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

The authors assessed the effects on Wisconsin Card Sort (WCST) performance and psychiatric symptoms of 30 mg d-amphetamine, a dopamine and norepinephrine agonist, vs placebo in nine patients with schizotypal personality disorder (SPD). Patients, particularly those who made more perseverative errors, demonstrated amphetamine-associated improvement on WCST performance. The data in this preliminary study suggest that some of the cognitive dysfunction present in SPD may improve with amphetamine challenge.

Original language	English
Pages (from-to)	29-32
Number of pages	4
Journal	Schizophrenia Research
Volume	20
Issue number	1-2
DOIs	https://doi.org/10.1016/0920-9964(95)00002-X
State	Published - May 1996

Keywords

Wisconsin Card Sort Test
amphetamine
schizophrenia
schizotypal personality disorder

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10.1016/0920-9964(95)00002-X

Cite this

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title = "D-amphetamine challenge effects on Wisconsin Card Sort Test. Performance in schizotypal personality disorder",

abstract = "The authors assessed the effects on Wisconsin Card Sort (WCST) performance and psychiatric symptoms of 30 mg d-amphetamine, a dopamine and norepinephrine agonist, vs placebo in nine patients with schizotypal personality disorder (SPD). Patients, particularly those who made more perseverative errors, demonstrated amphetamine-associated improvement on WCST performance. The data in this preliminary study suggest that some of the cognitive dysfunction present in SPD may improve with amphetamine challenge.",

keywords = "Wisconsin Card Sort Test, amphetamine, schizophrenia, schizotypal personality disorder",

author = "Siegel, \{Benjamin V.\} and Trestman, \{Robert L.\} and S{\'e}amus O'Flaithbheartaigh and Vivian Mitropoulou and Farooq Amin and Richelle Kirrane and Jeremy Silverman and James Schmeidler and Keefe, \{Richard S.E.\} and Siever, \{Larry J.\}",

note = "Funding Information: This study was supported by Dr. Siever's VA Merit Award 7609-20 and NIMH grant MH42827-02, as well as NARSAD Young Investigator's Awards to Drs. Siegel and Trestman.",

year = "1996",

month = may,

doi = "10.1016/0920-9964(95)00002-X",

language = "English",

volume = "20",

pages = "29--32",

journal = "Schizophrenia Research",

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AU - Siegel, Benjamin V.

AU - Trestman, Robert L.

AU - O'Flaithbheartaigh, Séamus

AU - Mitropoulou, Vivian

AU - Amin, Farooq

AU - Kirrane, Richelle

AU - Silverman, Jeremy

AU - Schmeidler, James

AU - Keefe, Richard S.E.

AU - Siever, Larry J.

N1 - Funding Information: This study was supported by Dr. Siever's VA Merit Award 7609-20 and NIMH grant MH42827-02, as well as NARSAD Young Investigator's Awards to Drs. Siegel and Trestman.

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N2 - The authors assessed the effects on Wisconsin Card Sort (WCST) performance and psychiatric symptoms of 30 mg d-amphetamine, a dopamine and norepinephrine agonist, vs placebo in nine patients with schizotypal personality disorder (SPD). Patients, particularly those who made more perseverative errors, demonstrated amphetamine-associated improvement on WCST performance. The data in this preliminary study suggest that some of the cognitive dysfunction present in SPD may improve with amphetamine challenge.

AB - The authors assessed the effects on Wisconsin Card Sort (WCST) performance and psychiatric symptoms of 30 mg d-amphetamine, a dopamine and norepinephrine agonist, vs placebo in nine patients with schizotypal personality disorder (SPD). Patients, particularly those who made more perseverative errors, demonstrated amphetamine-associated improvement on WCST performance. The data in this preliminary study suggest that some of the cognitive dysfunction present in SPD may improve with amphetamine challenge.

KW - Wisconsin Card Sort Test

KW - amphetamine

KW - schizophrenia

KW - schizotypal personality disorder

UR - https://www.scopus.com/pages/publications/0030152031

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DO - 10.1016/0920-9964(95)00002-X

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JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 1-2

ER -

D-amphetamine challenge effects on Wisconsin Card Sort Test. Performance in schizotypal personality disorder

Abstract

Keywords

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