Cytomegalovirus ventriculoencephalitis in a bone marrow transplant recipient receiving antiviral maintenance: Clinical and molecular evidence of drug resistance

Susan K. Seo; Anne Regan; Tomas Cihlar; Deborah C. Lin; Farid Boulad; Diane George; Vinod K. Prasad; Timothy E. Kiehn; Bruce Polsky

doi:10.1086/323022

Cytomegalovirus ventriculoencephalitis in a bone marrow transplant recipient receiving antiviral maintenance: Clinical and molecular evidence of drug resistance

Susan K. Seo, Anne Regan, Tomas Cihlar, Deborah C. Lin, Farid Boulad, Diane George, Vinod K. Prasad, Timothy E. Kiehn, Bruce Polsky

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Abstract

We describe a case of CMV ventriculoencephalitis in a severely immunocompromised bone marrow transplant recipient who was receiving combination therapy with ganciclovir and foscarnet for treatment of viremia and retinitis. Analysis of sequential viral isolates recovered from the patient's cerebrospinal fluid suggested that disease developed because of the presence of viral resistance and, possibly, low tissue penetration of antiviral agents.

Original language	English
Pages (from-to)	e105-108
Journal	Clinical Infectious Diseases
Volume	33
Issue number	9
DOIs	https://doi.org/10.1086/323022
State	Published - 1 Nov 2001
Externally published	Yes

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title = "Cytomegalovirus ventriculoencephalitis in a bone marrow transplant recipient receiving antiviral maintenance: Clinical and molecular evidence of drug resistance",

abstract = "We describe a case of CMV ventriculoencephalitis in a severely immunocompromised bone marrow transplant recipient who was receiving combination therapy with ganciclovir and foscarnet for treatment of viremia and retinitis. Analysis of sequential viral isolates recovered from the patient's cerebrospinal fluid suggested that disease developed because of the presence of viral resistance and, possibly, low tissue penetration of antiviral agents.",

author = "Seo, {Susan K.} and Anne Regan and Tomas Cihlar and Lin, {Deborah C.} and Farid Boulad and Diane George and Prasad, {Vinod K.} and Kiehn, {Timothy E.} and Bruce Polsky",

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T2 - Clinical and molecular evidence of drug resistance

AU - Seo, Susan K.

AU - Regan, Anne

AU - Cihlar, Tomas

AU - Lin, Deborah C.

AU - Boulad, Farid

AU - George, Diane

AU - Prasad, Vinod K.

AU - Kiehn, Timothy E.

AU - Polsky, Bruce

PY - 2001/11/1

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N2 - We describe a case of CMV ventriculoencephalitis in a severely immunocompromised bone marrow transplant recipient who was receiving combination therapy with ganciclovir and foscarnet for treatment of viremia and retinitis. Analysis of sequential viral isolates recovered from the patient's cerebrospinal fluid suggested that disease developed because of the presence of viral resistance and, possibly, low tissue penetration of antiviral agents.

AB - We describe a case of CMV ventriculoencephalitis in a severely immunocompromised bone marrow transplant recipient who was receiving combination therapy with ganciclovir and foscarnet for treatment of viremia and retinitis. Analysis of sequential viral isolates recovered from the patient's cerebrospinal fluid suggested that disease developed because of the presence of viral resistance and, possibly, low tissue penetration of antiviral agents.

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JF - Clinical Infectious Diseases

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Cytomegalovirus ventriculoencephalitis in a bone marrow transplant recipient receiving antiviral maintenance: Clinical and molecular evidence of drug resistance

Abstract

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