Cytomegalovirus ventriculoencephalitis in a bone marrow transplant recipient receiving antiviral maintenance: Clinical and molecular evidence of drug resistance

Susan K. Seo, Anne Regan, Tomas Cihlar, Deborah C. Lin, Farid Boulad, Diane George, Vinod K. Prasad, Timothy E. Kiehn, Bruce Polsky

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

We describe a case of CMV ventriculoencephalitis in a severely immunocompromised bone marrow transplant recipient who was receiving combination therapy with ganciclovir and foscarnet for treatment of viremia and retinitis. Analysis of sequential viral isolates recovered from the patient's cerebrospinal fluid suggested that disease developed because of the presence of viral resistance and, possibly, low tissue penetration of antiviral agents.

Original languageEnglish
Pages (from-to)e105-108
JournalClinical Infectious Diseases
Volume33
Issue number9
DOIs
StatePublished - 1 Nov 2001
Externally publishedYes

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