Cytomegalovirus retinitis after treatment with topical difluprednate in an aphakic eye of an immunocompetent patient

Richard I. Kaplan; Brian K. Do; Ronald C. Gentile; Sanjay R. Kedhar

doi:10.1016/j.ajoc.2019.100552

Cytomegalovirus retinitis after treatment with topical difluprednate in an aphakic eye of an immunocompetent patient

Richard I. Kaplan, Brian K. Do, Ronald C. Gentile, Sanjay R. Kedhar

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Purpose: To report a case of an immunocompetent 64-year-old man who developed cytomegalovirus (CMV) retinitis after using topical difluprednate. Observations: A 64-year-old man with type 2 diabetes developed hemorrhagic retinitis while using topical difluprednate after penetrating keratoplasty. Polymerase chain reaction of the vitreous was positive for CMV DNA. Complete blood count was within normal limits and 4th generation human immunodeficiency virus assay was negative. The retinitis resolved with oral valgancyclovir and intravitreal foscarnet injections. Conclusion and importance: CMV retinitis may occur after topical difluprednate in an immunocompetent patient.

Original language	English
Article number	100552
Journal	American Journal of Ophthalmology Case Reports
Volume	16
DOIs	https://doi.org/10.1016/j.ajoc.2019.100552
State	Published - Dec 2019
Externally published	Yes

Keywords

Cytomegalovirus retinitis
Difluprednate
Topical steroid

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10.1016/j.ajoc.2019.100552

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title = "Cytomegalovirus retinitis after treatment with topical difluprednate in an aphakic eye of an immunocompetent patient",

abstract = "Purpose: To report a case of an immunocompetent 64-year-old man who developed cytomegalovirus (CMV) retinitis after using topical difluprednate. Observations: A 64-year-old man with type 2 diabetes developed hemorrhagic retinitis while using topical difluprednate after penetrating keratoplasty. Polymerase chain reaction of the vitreous was positive for CMV DNA. Complete blood count was within normal limits and 4th generation human immunodeficiency virus assay was negative. The retinitis resolved with oral valgancyclovir and intravitreal foscarnet injections. Conclusion and importance: CMV retinitis may occur after topical difluprednate in an immunocompetent patient.",

keywords = "Cytomegalovirus retinitis, Difluprednate, Topical steroid",

author = "Kaplan, {Richard I.} and Do, {Brian K.} and Gentile, {Ronald C.} and Kedhar, {Sanjay R.}",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2019",

month = dec,

doi = "10.1016/j.ajoc.2019.100552",

language = "English",

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journal = "American Journal of Ophthalmology Case Reports",

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T1 - Cytomegalovirus retinitis after treatment with topical difluprednate in an aphakic eye of an immunocompetent patient

AU - Kaplan, Richard I.

AU - Do, Brian K.

AU - Gentile, Ronald C.

AU - Kedhar, Sanjay R.

PY - 2019/12

Y1 - 2019/12

N2 - Purpose: To report a case of an immunocompetent 64-year-old man who developed cytomegalovirus (CMV) retinitis after using topical difluprednate. Observations: A 64-year-old man with type 2 diabetes developed hemorrhagic retinitis while using topical difluprednate after penetrating keratoplasty. Polymerase chain reaction of the vitreous was positive for CMV DNA. Complete blood count was within normal limits and 4th generation human immunodeficiency virus assay was negative. The retinitis resolved with oral valgancyclovir and intravitreal foscarnet injections. Conclusion and importance: CMV retinitis may occur after topical difluprednate in an immunocompetent patient.

AB - Purpose: To report a case of an immunocompetent 64-year-old man who developed cytomegalovirus (CMV) retinitis after using topical difluprednate. Observations: A 64-year-old man with type 2 diabetes developed hemorrhagic retinitis while using topical difluprednate after penetrating keratoplasty. Polymerase chain reaction of the vitreous was positive for CMV DNA. Complete blood count was within normal limits and 4th generation human immunodeficiency virus assay was negative. The retinitis resolved with oral valgancyclovir and intravitreal foscarnet injections. Conclusion and importance: CMV retinitis may occur after topical difluprednate in an immunocompetent patient.

KW - Cytomegalovirus retinitis

KW - Difluprednate

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M3 - Article

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Cytomegalovirus retinitis after treatment with topical difluprednate in an aphakic eye of an immunocompetent patient

Abstract

Keywords

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