Cytomegalovirus Polyradiculopathy in the Modern Age of Human Immunodeficiency Virus Therapies

Timothy Lee, Sean Liu, Emma Kaplan-Lewis, Mikyung Lee

Research output: Contribution to journalArticlepeer-review


Cytomegalovirus (CMV) polyradiculopathy in human immunodeficiency virus-infected patients is an increasingly rare disease given the widespread availability of effective antiretroviral therapy. Here, we describe a case of CMV polyradiculopathy in a man following the initiation of antiretrovirals. The patient presented with a 2-week history of rapidly progressing bilateral lower extremity weakness resulting in paraplegia; he was diagnosed with CMV polyradiculopathy based on cerebrospinal fluid and magnetic resonance imaging findings. Treatment with ganciclovir, foscarnet, and antiretroviral therapy resulted in rapid reduction of CMV viral load in cerebrospinal fluid and halting of disease progression. Six months after presentation, the patient continues to show improvement in lower extremity strength and has regained the ability to ambulate without assistance for short distances.

Original languageEnglish
Pages (from-to)e74-e75
JournalInfectious Diseases in Clinical Practice
Issue number6
StatePublished - 1 Nov 2016


  • CMV polyradiculopathy
  • HIV
  • foscarnet
  • ganciclovir


Dive into the research topics of 'Cytomegalovirus Polyradiculopathy in the Modern Age of Human Immunodeficiency Virus Therapies'. Together they form a unique fingerprint.

Cite this