Cytomegalovirus in liver transplant recipients

David Herman, Hyosun Han

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations

Abstract

Purpose of review: Cytomegalovirus (CMV) is the most common opportunistic infection following solid-organ transplant and remains a cause of life-threatening disease and allograft rejection in liver transplant recipients. The purpose of this review is to highlight the current strategies in diagnosis and management of this disease in this vulnerable population. Recent findings: Identification of high-risk individuals and aggressive treatment with antiviral agents, either via prophylaxis or by early initiation during active disease, has become the standard of care. Despite this, CMV continues to exert a significant effect, remaining a major cause of morbidity and mortality. Summary: Given these findings, continuing efforts are underway to determine whether further therapy, vaccination, or alternative management strategies may improve outcomes in solid-organ transplant recipients. Until that time, however, aggressive monitoring of post-transplant patients for signs and symptoms of CMV infection is the best strategy to prevent solid-organ loss and death.

Original languageEnglish
Pages (from-to)345-350
Number of pages6
JournalCurrent Opinion in Organ Transplantation
Volume22
Issue number4
DOIs
StatePublished - 1 Aug 2017
Externally publishedYes

Keywords

  • cytomegalovirus
  • immunosuppression
  • reactivation
  • serostatus

Fingerprint

Dive into the research topics of 'Cytomegalovirus in liver transplant recipients'. Together they form a unique fingerprint.

Cite this