Cytokines and the Th1/Th2 paradigm in transplantation

Peter Nickerson; Wolfgang Steurer; Jürg Steiger; Xinxiao Zheng; Alan W. Steele; Terry B. Strom

doi:10.1016/0952-7915(94)90081-7

Cytokines and the Th1/Th2 paradigm in transplantation

Peter Nickerson, Wolfgang Steurer, Jürg Steiger, Xinxiao Zheng, Alan W. Steele, Terry B. Strom

Research output: Contribution to journal › Article › peer-review

218 Scopus citations

Abstract

With studies elucidating the cytokine programs associated with T-cell activation, allograft rejection and tolerance induction, the Thl/Th2 paradigm has become a unifying model to explain the observed cytokine profiles. The proof that these cytokines mediate allograft tolerance, however, is at best indirect. More recent studies highlighting the redundant and pleiotropic nature of cytokine networks suggest that the Thl/Th2 paradigm may not be sufficient to explain fully the mechanisms underlying allograft tolerance.

Original language	English
Pages (from-to)	757-764
Number of pages	8
Journal	Current Opinion in Immunology
Volume	6
Issue number	5
DOIs	https://doi.org/10.1016/0952-7915(94)90081-7
State	Published - 1994
Externally published	Yes

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@article{d3f86f3849b3406d85a25ca1ecc54861,

title = "Cytokines and the Th1/Th2 paradigm in transplantation",

abstract = "With studies elucidating the cytokine programs associated with T-cell activation, allograft rejection and tolerance induction, the Thl/Th2 paradigm has become a unifying model to explain the observed cytokine profiles. The proof that these cytokines mediate allograft tolerance, however, is at best indirect. More recent studies highlighting the redundant and pleiotropic nature of cytokine networks suggest that the Thl/Th2 paradigm may not be sufficient to explain fully the mechanisms underlying allograft tolerance.",

author = "Peter Nickerson and Wolfgang Steurer and J{\"u}rg Steiger and Xinxiao Zheng and Steele, {Alan W.} and Strom, {Terry B.}",

note = "Funding Information: PW Nickerson is supported by the MRC of Canada, W Steurer is supported by the Max Kade Foundation Inc., J Striger is supported by the Swiss National Foundation, AW Steele is supported by the American Heart Association and the National Kidney Foundation of America, and TU Strom is supported in part by grants provided by the National Institutes of Health.",

year = "1994",

doi = "10.1016/0952-7915(94)90081-7",

language = "English",

volume = "6",

pages = "757--764",

journal = "Current Opinion in Immunology",

issn = "0952-7915",

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T1 - Cytokines and the Th1/Th2 paradigm in transplantation

AU - Nickerson, Peter

AU - Steurer, Wolfgang

AU - Steiger, Jürg

AU - Zheng, Xinxiao

AU - Steele, Alan W.

AU - Strom, Terry B.

N1 - Funding Information: PW Nickerson is supported by the MRC of Canada, W Steurer is supported by the Max Kade Foundation Inc., J Striger is supported by the Swiss National Foundation, AW Steele is supported by the American Heart Association and the National Kidney Foundation of America, and TU Strom is supported in part by grants provided by the National Institutes of Health.

PY - 1994

Y1 - 1994

N2 - With studies elucidating the cytokine programs associated with T-cell activation, allograft rejection and tolerance induction, the Thl/Th2 paradigm has become a unifying model to explain the observed cytokine profiles. The proof that these cytokines mediate allograft tolerance, however, is at best indirect. More recent studies highlighting the redundant and pleiotropic nature of cytokine networks suggest that the Thl/Th2 paradigm may not be sufficient to explain fully the mechanisms underlying allograft tolerance.

AB - With studies elucidating the cytokine programs associated with T-cell activation, allograft rejection and tolerance induction, the Thl/Th2 paradigm has become a unifying model to explain the observed cytokine profiles. The proof that these cytokines mediate allograft tolerance, however, is at best indirect. More recent studies highlighting the redundant and pleiotropic nature of cytokine networks suggest that the Thl/Th2 paradigm may not be sufficient to explain fully the mechanisms underlying allograft tolerance.

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U2 - 10.1016/0952-7915(94)90081-7

DO - 10.1016/0952-7915(94)90081-7

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SN - 0952-7915

VL - 6

SP - 757

EP - 764

JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

IS - 5

ER -

Cytokines and the Th1/Th2 paradigm in transplantation

Abstract

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