Cytokines alter IgA1 O-glycosylation by dysregulating C1GalT1 and ST6GalNAc-II enzymes

Hitoshi Suzuki, Milan Raska, Koshi Yamada, Zina Moldoveanu, Bruce A. Julian, Robert J. Wyatt, Yasuhiko Tomino, Ali G. Gharavi, Jan Novak

Research output: Contribution to journalArticlepeer-review

123 Scopus citations

Abstract

Background: IgA1-producing cells of IgA nephropathy patients secrete IgA1 with galactose-deficientO-glycans; these IgA1 molecules form nephritogenic immune complexes. Results: Cytokines IL-6 and IL-4 accentuate IgA1 galactose deficiency via modulation of key glycosyltransferases. Conclusion: Some cytokines alter IgA1 O-glycosylation and increase production of nephritogenic IgA1 glycoforms. Significance: These data provide a mechanism explaining increased immune-complex formation in IgA nephropathy patients.

Original languageEnglish
Pages (from-to)5330-5339
Number of pages10
JournalJournal of Biological Chemistry
Volume289
Issue number8
DOIs
StatePublished - 21 Feb 2014
Externally publishedYes

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