Cytokine Targeted Therapeutics for Alopecia Areata: Lessons from Atopic Dermatitis and Other Inflammatory Skin Diseases

Kunal Malik, Emma Guttman-Yassky

Research output: Contribution to journalComment/debate

22 Scopus citations

Abstract

Alopecia areata is a T-cell-mediated disease that shares phenotypic similarities with other inflammatory diseases, particularly atopic dermatitis, and lacks safe, effective, mechanism-specific treatments. Increasing data suggests that alopecia areata harbors contributions of T helper type 1, T helper type 2, T helper type 17/IL-23, and phosphodiesterase pathways. Antagonism of these axes is undergoing evaluation, and might elucidate the underlying molecular circuitry of alopecia areata, advancing the translational revolution for this disease.

Original languageEnglish
Pages (from-to)S62-S64
JournalJournal of Investigative Dermatology Symposium Proceedings
Volume19
Issue number1
DOIs
StatePublished - Jan 2018

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