Cytokine kinetics of Zika virus-infected patients from acute to reconvalescent phase

Dennis Tappe; José Vicente Pérez-Girón; Lorenzo Zammarchi; Jürgen Rissland; Davis F. Ferreira; Thomas Jaenisch; Sergio Gómez-Medina; Stephan Günther; Alessandro Bartoloni; César Muñoz-Fontela; Jonas Schmidt-Chanasit

doi:10.1007/s00430-015-0445-7

Cytokine kinetics of Zika virus-infected patients from acute to reconvalescent phase

Dennis Tappe, José Vicente Pérez-Girón, Lorenzo Zammarchi, Jürgen Rissland, Davis F. Ferreira, Thomas Jaenisch, Sergio Gómez-Medina, Stephan Günther, Alessandro Bartoloni, César Muñoz-Fontela, Jonas Schmidt-Chanasit

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127 Scopus citations

Abstract

Zika virus is an emerging mosquito-borne flavivirus currently causing large epidemics in the Pacific Ocean region and Brazil. Clinically, Zika fever resembles dengue fever, but is less severe. Whereas the clinical syndrome and laboratory diagnostic procedures have been described, little attention was paid to the immunology of the disease and its possible use for clinical follow-up of patients. Here, we investigate the role of cytokines in the pathogenesis of Zika fever in travelers returning from Asia, the Pacific, and Brazil. Polyfunctional T cell activation (Th1, Th2, Th9, and Th17 response) was seen during the acute phase characterized by respective cytokine level increases, followed by a decrease in the reconvalescent phase.

Original language	English
Pages (from-to)	269-273
Number of pages	5
Journal	Medical Microbiology and Immunology
Volume	205
Issue number	3
DOIs	https://doi.org/10.1007/s00430-015-0445-7
State	Published - 1 Jun 2016
Externally published	Yes

Keywords

Arbovirus
Cytokine
Flavivirus
Outbreak
Zika fever
Zika virus

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10.1007/s00430-015-0445-7

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Tappe, D., Pérez-Girón, J. V., Zammarchi, L., Rissland, J., Ferreira, D. F., Jaenisch, T., Gómez-Medina, S., Günther, S., Bartoloni, A., Muñoz-Fontela, C., & Schmidt-Chanasit, J. (2016). Cytokine kinetics of Zika virus-infected patients from acute to reconvalescent phase. Medical Microbiology and Immunology, 205(3), 269-273. https://doi.org/10.1007/s00430-015-0445-7

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title = "Cytokine kinetics of Zika virus-infected patients from acute to reconvalescent phase",

abstract = "Zika virus is an emerging mosquito-borne flavivirus currently causing large epidemics in the Pacific Ocean region and Brazil. Clinically, Zika fever resembles dengue fever, but is less severe. Whereas the clinical syndrome and laboratory diagnostic procedures have been described, little attention was paid to the immunology of the disease and its possible use for clinical follow-up of patients. Here, we investigate the role of cytokines in the pathogenesis of Zika fever in travelers returning from Asia, the Pacific, and Brazil. Polyfunctional T cell activation (Th1, Th2, Th9, and Th17 response) was seen during the acute phase characterized by respective cytokine level increases, followed by a decrease in the reconvalescent phase.",

keywords = "Arbovirus, Cytokine, Flavivirus, Outbreak, Zika fever, Zika virus",

author = "Dennis Tappe and P{\'e}rez-Gir{\'o}n, {Jos{\'e} Vicente} and Lorenzo Zammarchi and J{\"u}rgen Rissland and Ferreira, {Davis F.} and Thomas Jaenisch and Sergio G{\'o}mez-Medina and Stephan G{\"u}nther and Alessandro Bartoloni and C{\'e}sar Mu{\~n}oz-Fontela and Jonas Schmidt-Chanasit",

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year = "2016",

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doi = "10.1007/s00430-015-0445-7",

language = "English",

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Tappe, D, Pérez-Girón, JV, Zammarchi, L, Rissland, J, Ferreira, DF, Jaenisch, T, Gómez-Medina, S, Günther, S, Bartoloni, A, Muñoz-Fontela, C & Schmidt-Chanasit, J 2016, 'Cytokine kinetics of Zika virus-infected patients from acute to reconvalescent phase', Medical Microbiology and Immunology, vol. 205, no. 3, pp. 269-273. https://doi.org/10.1007/s00430-015-0445-7

TY - JOUR

T1 - Cytokine kinetics of Zika virus-infected patients from acute to reconvalescent phase

AU - Tappe, Dennis

AU - Pérez-Girón, José Vicente

AU - Zammarchi, Lorenzo

AU - Rissland, Jürgen

AU - Ferreira, Davis F.

AU - Jaenisch, Thomas

AU - Gómez-Medina, Sergio

AU - Günther, Stephan

AU - Bartoloni, Alessandro

AU - Muñoz-Fontela, César

AU - Schmidt-Chanasit, Jonas

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Zika virus is an emerging mosquito-borne flavivirus currently causing large epidemics in the Pacific Ocean region and Brazil. Clinically, Zika fever resembles dengue fever, but is less severe. Whereas the clinical syndrome and laboratory diagnostic procedures have been described, little attention was paid to the immunology of the disease and its possible use for clinical follow-up of patients. Here, we investigate the role of cytokines in the pathogenesis of Zika fever in travelers returning from Asia, the Pacific, and Brazil. Polyfunctional T cell activation (Th1, Th2, Th9, and Th17 response) was seen during the acute phase characterized by respective cytokine level increases, followed by a decrease in the reconvalescent phase.

AB - Zika virus is an emerging mosquito-borne flavivirus currently causing large epidemics in the Pacific Ocean region and Brazil. Clinically, Zika fever resembles dengue fever, but is less severe. Whereas the clinical syndrome and laboratory diagnostic procedures have been described, little attention was paid to the immunology of the disease and its possible use for clinical follow-up of patients. Here, we investigate the role of cytokines in the pathogenesis of Zika fever in travelers returning from Asia, the Pacific, and Brazil. Polyfunctional T cell activation (Th1, Th2, Th9, and Th17 response) was seen during the acute phase characterized by respective cytokine level increases, followed by a decrease in the reconvalescent phase.

KW - Arbovirus

KW - Cytokine

KW - Flavivirus

KW - Outbreak

KW - Zika fever

KW - Zika virus

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U2 - 10.1007/s00430-015-0445-7

DO - 10.1007/s00430-015-0445-7

M3 - Article

C2 - 26702627

AN - SCOPUS:84951866989

SN - 0300-8584

VL - 205

SP - 269

EP - 273

JO - Medical Microbiology and Immunology

JF - Medical Microbiology and Immunology

IS - 3

ER -

Cytokine kinetics of Zika virus-infected patients from acute to reconvalescent phase

Abstract

Keywords

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