TY - JOUR
T1 - Cytokine-chemokine and apoptotic signatures in patients with hepatitis C
AU - Neuman, Manuela G.
AU - Benhamou, Jean Pierre
AU - Marcellin, Patrick
AU - Valla, Dominique
AU - Malkiewicz, Izabella M.
AU - Katz, Gad G.
AU - Trepo, Cristhian
AU - Bourliere, Marc
AU - Cameron, Ross G.
AU - Cohen, Lawrence
AU - Morgan, Mary
AU - Schmilovitz-Weiss, Hemda
AU - Ben-Ari, Ziv
N1 - Funding Information:
This article was presented at the 7 th International Symposium on Cytokines and Chemokines (Montréal, Québec, Canada, September 7-9, 2005). Dr Manuela G. Neuman, scientific organizer of the symposium, is grateful for the financial support given by the Institute of Infection and Immunity of the Canadian Institutes of Health Research and by the National Institute on Alcohol Abuse and Alcoholism, National Institute of Health, USA.
Funding Information:
Supported in part by Schering-Plough (Kenilworth, NJ), who provided cytokine kits and by a grant from the Sackler Faculty of Medicine, Tel-Aviv University, Israel (Z.B.-A., H.S.-W., M.G.N.).
PY - 2007/3
Y1 - 2007/3
N2 - Cytokines and chemokines are proteins that play a critical role in the regulation of immunity and inflammation in patients with chronic Hepatitis C. The aim of our study was to correlate serum cytokines, chemokines and apoptosis in non-treated chronic hepatitis C patients with various degrees of inflammation and fibrosis. We studied 778 patients: 59 had low Knodell fibrosis score and low Knodell histological activity index; 372 had mild fibrosis and low histological activity index; 270 had moderate fibrosis and moderate histological activity index; and, 77 had high fibrosis and high histological activity index on their biopsy. Serum cytokines, chemokines and apoptosis were measured by enzyme-linked-immunosorbent-assay. Multivariate analysis was employed for statistical purposes. A positive correlation was seen between the degree of inflammation and tumor necrosis factor-alpha (TNF-α) levels (r=0.92) in non-cirrhotic patients and between interleukin 2 in all patients (r=0.85). Interleukin-8 increased significantly at higher histological activity indices and continued to increase in patients with cirrhosis. Transforming growth factor-beta (TGF-β) levels increased significantly with the severity of fibrosis, but decreased in cirrhotics. In conclusion, cytokines, chemokines and apoptosis levels reflect the progression of inflammation and fibrosis in hepatitis C infected patients, but their signatures differ.
AB - Cytokines and chemokines are proteins that play a critical role in the regulation of immunity and inflammation in patients with chronic Hepatitis C. The aim of our study was to correlate serum cytokines, chemokines and apoptosis in non-treated chronic hepatitis C patients with various degrees of inflammation and fibrosis. We studied 778 patients: 59 had low Knodell fibrosis score and low Knodell histological activity index; 372 had mild fibrosis and low histological activity index; 270 had moderate fibrosis and moderate histological activity index; and, 77 had high fibrosis and high histological activity index on their biopsy. Serum cytokines, chemokines and apoptosis were measured by enzyme-linked-immunosorbent-assay. Multivariate analysis was employed for statistical purposes. A positive correlation was seen between the degree of inflammation and tumor necrosis factor-alpha (TNF-α) levels (r=0.92) in non-cirrhotic patients and between interleukin 2 in all patients (r=0.85). Interleukin-8 increased significantly at higher histological activity indices and continued to increase in patients with cirrhosis. Transforming growth factor-beta (TGF-β) levels increased significantly with the severity of fibrosis, but decreased in cirrhotics. In conclusion, cytokines, chemokines and apoptosis levels reflect the progression of inflammation and fibrosis in hepatitis C infected patients, but their signatures differ.
UR - https://www.scopus.com/pages/publications/33847185260
U2 - 10.1016/j.trsl.2006.11.002
DO - 10.1016/j.trsl.2006.11.002
M3 - Article
C2 - 17320798
AN - SCOPUS:33847185260
SN - 1931-5244
VL - 149
SP - 126
EP - 136
JO - Translational Research
JF - Translational Research
IS - 3
ER -