Cytokeratin positivity in paraffin-embedded malignant melanomas: Comparative study of KL1, A4 and Lu5 antibodies

Monika Korabiowska; Gösta Fischer; Anja Steinacker; Jerzy Stachura; Carlos Cordon-Cardo; Ulrich Brinck

Cytokeratin positivity in paraffin-embedded malignant melanomas: Comparative study of KL1, A4 and Lu5 antibodies

Monika Korabiowska, Gösta Fischer, Anja Steinacker, Jerzy Stachura, Carlos Cordon-Cardo, Ulrich Brinck

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The unclear role of cytokeratin (CK) in the progression and diagnostics of malignant melanomas stimulated us to compare the reactivity of three antibodies directed to CK in 109 paraffin-embedded melanomas. By far the majority of melanomas did not express cytokeratin even at the <1% level, only vimentin. In about 6% of melanomas it was possible to find CK expression ranging between 3 and 40% of melanoma cells. There was a correlation between CK expression and pT-stage. Cytokeratin-expressing tumours were found in the more advanced pT-stages. The independent prognostic values of none of the three CK antibodies investigated could be shown.

Original language	English
Pages (from-to)	3203-3207
Number of pages	5
Journal	Anticancer Research
Volume	24
Issue number	5 B
State	Published - Sep 2004
Externally published	Yes

Keywords

Cytokeratin
Malignant melanoma

Cite this

@article{fa4027ece56a47348485922788a8c1e2,

title = "Cytokeratin positivity in paraffin-embedded malignant melanomas: Comparative study of KL1, A4 and Lu5 antibodies",

abstract = "The unclear role of cytokeratin (CK) in the progression and diagnostics of malignant melanomas stimulated us to compare the reactivity of three antibodies directed to CK in 109 paraffin-embedded melanomas. By far the majority of melanomas did not express cytokeratin even at the <1% level, only vimentin. In about 6% of melanomas it was possible to find CK expression ranging between 3 and 40% of melanoma cells. There was a correlation between CK expression and pT-stage. Cytokeratin-expressing tumours were found in the more advanced pT-stages. The independent prognostic values of none of the three CK antibodies investigated could be shown.",

keywords = "Cytokeratin, Malignant melanoma",

author = "Monika Korabiowska and G{\"o}sta Fischer and Anja Steinacker and Jerzy Stachura and Carlos Cordon-Cardo and Ulrich Brinck",

year = "2004",

month = sep,

language = "English",

volume = "24",

pages = "3203--3207",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "5 B",

}

TY - JOUR

T1 - Cytokeratin positivity in paraffin-embedded malignant melanomas

T2 - Comparative study of KL1, A4 and Lu5 antibodies

AU - Korabiowska, Monika

AU - Fischer, Gösta

AU - Steinacker, Anja

AU - Stachura, Jerzy

AU - Cordon-Cardo, Carlos

AU - Brinck, Ulrich

PY - 2004/9

Y1 - 2004/9

N2 - The unclear role of cytokeratin (CK) in the progression and diagnostics of malignant melanomas stimulated us to compare the reactivity of three antibodies directed to CK in 109 paraffin-embedded melanomas. By far the majority of melanomas did not express cytokeratin even at the <1% level, only vimentin. In about 6% of melanomas it was possible to find CK expression ranging between 3 and 40% of melanoma cells. There was a correlation between CK expression and pT-stage. Cytokeratin-expressing tumours were found in the more advanced pT-stages. The independent prognostic values of none of the three CK antibodies investigated could be shown.

AB - The unclear role of cytokeratin (CK) in the progression and diagnostics of malignant melanomas stimulated us to compare the reactivity of three antibodies directed to CK in 109 paraffin-embedded melanomas. By far the majority of melanomas did not express cytokeratin even at the <1% level, only vimentin. In about 6% of melanomas it was possible to find CK expression ranging between 3 and 40% of melanoma cells. There was a correlation between CK expression and pT-stage. Cytokeratin-expressing tumours were found in the more advanced pT-stages. The independent prognostic values of none of the three CK antibodies investigated could be shown.

KW - Cytokeratin

KW - Malignant melanoma

UR - http://www.scopus.com/inward/record.url?scp=6344293861&partnerID=8YFLogxK

M3 - Article

C2 - 15510611

AN - SCOPUS:6344293861

SN - 0250-7005

VL - 24

SP - 3203

EP - 3207

JO - Anticancer Research

JF - Anticancer Research

IS - 5 B

ER -

Cytokeratin positivity in paraffin-embedded malignant melanomas: Comparative study of KL1, A4 and Lu5 antibodies

Abstract

Keywords

Fingerprint

Cite this