Cytogenetic studies on H-2 alloantigenic loss variants selected from heterozygous tumors

Francis Wiener; Tina Dalianis; George Klein

doi:10.1007/BF01572275

Cytogenetic studies on H-2 alloantigenic loss variants selected from heterozygous tumors

Francis Wiener, Tina Dalianis, George Klein

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Transplantation, serological, and cytogenetic analyses on alloantigenic loss variants selected from heterozygous mouse tumors induced in F₁ animals demonstrate that both 17 chromosomes have been maintained in all variants despite complete loss of one H-2 complex. Small, subchromosomal deletion or mutation remains the most plausible explanation for alloantigenic loss variant formation in diploid or near-diploid heterozygous tumors.

Original language	English
Pages (from-to)	63-72
Number of pages	10
Journal	Immunogenetics
Volume	2
Issue number	1
DOIs	https://doi.org/10.1007/BF01572275
State	Published - Dec 1975
Externally published	Yes

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title = "Cytogenetic studies on H-2 alloantigenic loss variants selected from heterozygous tumors",

abstract = "Transplantation, serological, and cytogenetic analyses on alloantigenic loss variants selected from heterozygous mouse tumors induced in F1 animals demonstrate that both 17 chromosomes have been maintained in all variants despite complete loss of one H-2 complex. Small, subchromosomal deletion or mutation remains the most plausible explanation for alloantigenic loss variant formation in diploid or near-diploid heterozygous tumors.",

author = "Francis Wiener and Tina Dalianis and George Klein",

year = "1975",

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AU - Klein, George

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AB - Transplantation, serological, and cytogenetic analyses on alloantigenic loss variants selected from heterozygous mouse tumors induced in F1 animals demonstrate that both 17 chromosomes have been maintained in all variants despite complete loss of one H-2 complex. Small, subchromosomal deletion or mutation remains the most plausible explanation for alloantigenic loss variant formation in diploid or near-diploid heterozygous tumors.

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JO - Immunogenetics

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Cytogenetic studies on H-2 alloantigenic loss variants selected from heterozygous tumors

Abstract

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