Cytogenetic mapping of the trisomic segment of chromosome 15 in murine T-cell leukaemia [21]

Francis Wiener; Shinsuke Ohno; Jack Spira; Nechama Haran-Ghera; George Klein

doi:10.1038/275658a0

Cytogenetic mapping of the trisomic segment of chromosome 15 in murine T-cell leukaemia [21]

Francis Wiener, Shinsuke Ohno, Jack Spira, Nechama Haran-Ghera, George Klein

Research output: Contribution to journal › Letter › peer-review

62 Scopus citations

Abstract

A NONRANDOM cytogenetic change in the form of trisomy of chromosome 15 is associated with mouse T-cell leukaemia induced by various agents, such as Gross, Rad and Moloney leukaemia viruses, X rays and a chemical carcinogen, 7,12-dimethylbenz(a)anthracene (DMBA)^1-4. The uniformity of the chromosomal change and its apparent independence of the inducing agent suggest that it plays an important and perhaps decisive part in the neoplastic transformation of the mouse T lymphocyte. During our studies of the role of chromosome 15 and related factors in lymphoma development, we have investigated whether any particular region of the chromosome needs to be duplicated. Using DMBA to induce T-cell leukaemias in mice carrying chromosome 15 translocations, we have found, and now report that the duplicated chromosome segment is located distal to the T6 breakpoint of chromosome 15.

Original language	English
Pages (from-to)	658-660
Number of pages	3
Journal	Nature
Volume	275
Issue number	5681
DOIs	https://doi.org/10.1038/275658a0
State	Published - 1978
Externally published	Yes

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title = "Cytogenetic mapping of the trisomic segment of chromosome 15 in murine T-cell leukaemia [21]",

abstract = "A NONRANDOM cytogenetic change in the form of trisomy of chromosome 15 is associated with mouse T-cell leukaemia induced by various agents, such as Gross, Rad and Moloney leukaemia viruses, X rays and a chemical carcinogen, 7,12-dimethylbenz(a)anthracene (DMBA)1-4. The uniformity of the chromosomal change and its apparent independence of the inducing agent suggest that it plays an important and perhaps decisive part in the neoplastic transformation of the mouse T lymphocyte. During our studies of the role of chromosome 15 and related factors in lymphoma development, we have investigated whether any particular region of the chromosome needs to be duplicated. Using DMBA to induce T-cell leukaemias in mice carrying chromosome 15 translocations, we have found, and now report that the duplicated chromosome segment is located distal to the T6 breakpoint of chromosome 15.",

author = "Francis Wiener and Shinsuke Ohno and Jack Spira and Nechama Haran-Ghera and George Klein",

year = "1978",

doi = "10.1038/275658a0",

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journal = "Nature",

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T1 - Cytogenetic mapping of the trisomic segment of chromosome 15 in murine T-cell leukaemia [21]

AU - Wiener, Francis

AU - Ohno, Shinsuke

AU - Spira, Jack

AU - Haran-Ghera, Nechama

AU - Klein, George

PY - 1978

Y1 - 1978

N2 - A NONRANDOM cytogenetic change in the form of trisomy of chromosome 15 is associated with mouse T-cell leukaemia induced by various agents, such as Gross, Rad and Moloney leukaemia viruses, X rays and a chemical carcinogen, 7,12-dimethylbenz(a)anthracene (DMBA)1-4. The uniformity of the chromosomal change and its apparent independence of the inducing agent suggest that it plays an important and perhaps decisive part in the neoplastic transformation of the mouse T lymphocyte. During our studies of the role of chromosome 15 and related factors in lymphoma development, we have investigated whether any particular region of the chromosome needs to be duplicated. Using DMBA to induce T-cell leukaemias in mice carrying chromosome 15 translocations, we have found, and now report that the duplicated chromosome segment is located distal to the T6 breakpoint of chromosome 15.

AB - A NONRANDOM cytogenetic change in the form of trisomy of chromosome 15 is associated with mouse T-cell leukaemia induced by various agents, such as Gross, Rad and Moloney leukaemia viruses, X rays and a chemical carcinogen, 7,12-dimethylbenz(a)anthracene (DMBA)1-4. The uniformity of the chromosomal change and its apparent independence of the inducing agent suggest that it plays an important and perhaps decisive part in the neoplastic transformation of the mouse T lymphocyte. During our studies of the role of chromosome 15 and related factors in lymphoma development, we have investigated whether any particular region of the chromosome needs to be duplicated. Using DMBA to induce T-cell leukaemias in mice carrying chromosome 15 translocations, we have found, and now report that the duplicated chromosome segment is located distal to the T6 breakpoint of chromosome 15.

UR - https://www.scopus.com/pages/publications/0018118989

U2 - 10.1038/275658a0

DO - 10.1038/275658a0

M3 - Letter

C2 - 309097

AN - SCOPUS:0018118989

SN - 0028-0836

VL - 275

SP - 658

EP - 660

JO - Nature

JF - Nature

IS - 5681

ER -

Cytogenetic mapping of the trisomic segment of chromosome 15 in murine T-cell leukaemia [21]

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