TY - JOUR
T1 - Cytogenetic findings in siblings with a myelodysplastic syndrome
AU - Palmer, Catherine G.
AU - Heerema, Nyla A.
AU - Greist, Ann
AU - Tricot, Guido
AU - Hoffman, Ronald
PY - 1987/8
Y1 - 1987/8
N2 - A brother and sister, both in their third decade, presented 6 months apart with severe pancytopenia. Bone marrow examination demonstrated morphologic changes, characteristic of the myelodysplastic syndromes, subtype refractory anemia with excess of blasts; cytogenetic studies revealed complex but different karyotypic abnormalities in both siblings. No history of exposure to mutagenic agents was obtained; there was no evidence of congenital anomalies in the family. Both siblings died within 18 months of diagnosis from complications related to their disease. This report describes the clinical course and discusses the cytogenetic findings for both siblings.
AB - A brother and sister, both in their third decade, presented 6 months apart with severe pancytopenia. Bone marrow examination demonstrated morphologic changes, characteristic of the myelodysplastic syndromes, subtype refractory anemia with excess of blasts; cytogenetic studies revealed complex but different karyotypic abnormalities in both siblings. No history of exposure to mutagenic agents was obtained; there was no evidence of congenital anomalies in the family. Both siblings died within 18 months of diagnosis from complications related to their disease. This report describes the clinical course and discusses the cytogenetic findings for both siblings.
UR - https://www.scopus.com/pages/publications/0023221372
U2 - 10.1016/0165-4608(87)90006-9
DO - 10.1016/0165-4608(87)90006-9
M3 - Article
C2 - 3594414
AN - SCOPUS:0023221372
SN - 0165-4608
VL - 27
SP - 241
EP - 249
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 2
ER -