TY - JOUR
T1 - Cytogenetic analysis of 11 squamous cell carcinomas of the head and neck
AU - Rao, Pulivarthi H.
AU - Sreekantaiah, Chandrika
AU - Schantz, Stimson P.
AU - Chaganti, R. S.K.
N1 - Funding Information:
This investigation was supported in part by NIH grants CA-05826 and CA-08748. We thank Marilyn Evans for help with manuscript preparation.
PY - 1994/10/1
Y1 - 1994/10/1
N2 - We report clonal chromosomal abnormalities in short-term cultures of 11 squamous cell carcinomas of the head and neck. Recurrent deletions were seen at 1p13 (four cases), 6q15q26 (three cases), 6q21q25 (two cases), 12p11.2 (three cases), and 3p13-p23 (three cases). Structural aberrations affecting chromosome 11 with different breakpoints were seen in 7 of 11 tumors. Cytogenetic evidence for gene amplification in the form of homogeneously staining region (hsr) was seen in three tumors (two at 11q13). The results of this study shows that the 1p13, 3p13-p23, 6q15-q26, 6q21-q25, and 12p11.2 were frequently deleted in squamous cell carcinomas of the head and neck.
AB - We report clonal chromosomal abnormalities in short-term cultures of 11 squamous cell carcinomas of the head and neck. Recurrent deletions were seen at 1p13 (four cases), 6q15q26 (three cases), 6q21q25 (two cases), 12p11.2 (three cases), and 3p13-p23 (three cases). Structural aberrations affecting chromosome 11 with different breakpoints were seen in 7 of 11 tumors. Cytogenetic evidence for gene amplification in the form of homogeneously staining region (hsr) was seen in three tumors (two at 11q13). The results of this study shows that the 1p13, 3p13-p23, 6q15-q26, 6q21-q25, and 12p11.2 were frequently deleted in squamous cell carcinomas of the head and neck.
UR - https://www.scopus.com/pages/publications/0028149666
U2 - 10.1016/0165-4608(94)90150-3
DO - 10.1016/0165-4608(94)90150-3
M3 - Article
C2 - 7923085
AN - SCOPUS:0028149666
SN - 0165-4608
VL - 77
SP - 60
EP - 64
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 1
ER -