Cytogenetic abnormalities in multiple myeloma: poor prognosis linked to concomitant detection in random and focal lesion bone marrow samples and associated with high-risk gene expression profile

Yiming Zhou; Bijay Nair; John D. Shaughnessy; Marie Astrid Cartron; Jeff Haessler; Elias Anaissie; Frits Van Rhee; John Crowley; Bart Barlogie

doi:10.1111/j.1365-2141.2009.07670.x

Cytogenetic abnormalities in multiple myeloma: poor prognosis linked to concomitant detection in random and focal lesion bone marrow samples and associated with high-risk gene expression profile

Yiming Zhou, Bijay Nair, John D. Shaughnessy, Marie Astrid Cartron, Jeff Haessler, Elias Anaissie, Frits Van Rhee, John Crowley, Bart Barlogie

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The clinical significance of cytogenetic abnormalities (CA) present in randomly sampled (RS) or focal lesion (FL) bone marrow sites was examined in 419 untreated myeloma patients. Among 290 patients with gene expression profiling (GEP) data generated from RS sites, GEP-defined high-risk was present in 52% of the RS+/FL+ group but in only 9% of the remainder (P < 0·001). The RS+/FL+ constellation (18%) was an independent predictor of poor survival, also after adjusting for GEP-derived risk and TP53 status (Hazard ratio = 2·42, P = 0·004). The prevalence of high-risk myeloma in the RS+/FL+ group may reflect a dissemination-prone condition not shared by the other three groups.

Original language	English
Pages (from-to)	637-641
Number of pages	5
Journal	British Journal of Haematology
Volume	145
Issue number	5
DOIs	https://doi.org/10.1111/j.1365-2141.2009.07670.x
State	Published - Jun 2009
Externally published	Yes

Keywords

Cytogenetics
Focal lesions
Gene array
Myeloma
Prognosis

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10.1111/j.1365-2141.2009.07670.x

Cite this

Zhou, Y., Nair, B., Shaughnessy, J. D., Cartron, M. A., Haessler, J., Anaissie, E., Van Rhee, F., Crowley, J., & Barlogie, B. (2009). Cytogenetic abnormalities in multiple myeloma: poor prognosis linked to concomitant detection in random and focal lesion bone marrow samples and associated with high-risk gene expression profile. British Journal of Haematology, 145(5), 637-641. https://doi.org/10.1111/j.1365-2141.2009.07670.x

@article{bbe977fb6f3f4d0d890931900e58cc76,

title = "Cytogenetic abnormalities in multiple myeloma: poor prognosis linked to concomitant detection in random and focal lesion bone marrow samples and associated with high-risk gene expression profile",

abstract = "The clinical significance of cytogenetic abnormalities (CA) present in randomly sampled (RS) or focal lesion (FL) bone marrow sites was examined in 419 untreated myeloma patients. Among 290 patients with gene expression profiling (GEP) data generated from RS sites, GEP-defined high-risk was present in 52% of the RS+/FL+ group but in only 9% of the remainder (P < 0·001). The RS+/FL+ constellation (18%) was an independent predictor of poor survival, also after adjusting for GEP-derived risk and TP53 status (Hazard ratio = 2·42, P = 0·004). The prevalence of high-risk myeloma in the RS+/FL+ group may reflect a dissemination-prone condition not shared by the other three groups.",

keywords = "Cytogenetics, Focal lesions, Gene array, Myeloma, Prognosis",

author = "Yiming Zhou and Bijay Nair and Shaughnessy, {John D.} and Cartron, {Marie Astrid} and Jeff Haessler and Elias Anaissie and {Van Rhee}, Frits and John Crowley and Bart Barlogie",

year = "2009",

month = jun,

doi = "10.1111/j.1365-2141.2009.07670.x",

language = "English",

volume = "145",

pages = "637--641",

journal = "British Journal of Haematology",

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number = "5",

}

Zhou, Y, Nair, B, Shaughnessy, JD, Cartron, MA, Haessler, J, Anaissie, E, Van Rhee, F, Crowley, J & Barlogie, B 2009, 'Cytogenetic abnormalities in multiple myeloma: poor prognosis linked to concomitant detection in random and focal lesion bone marrow samples and associated with high-risk gene expression profile', British Journal of Haematology, vol. 145, no. 5, pp. 637-641. https://doi.org/10.1111/j.1365-2141.2009.07670.x

Cytogenetic abnormalities in multiple myeloma: poor prognosis linked to concomitant detection in random and focal lesion bone marrow samples and associated with high-risk gene expression profile. / Zhou, Yiming; Nair, Bijay; Shaughnessy, John D. et al.
In: British Journal of Haematology, Vol. 145, No. 5, 06.2009, p. 637-641.

Research output: Contribution to journal › Article › peer-review

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T2 - poor prognosis linked to concomitant detection in random and focal lesion bone marrow samples and associated with high-risk gene expression profile

AU - Zhou, Yiming

AU - Nair, Bijay

AU - Shaughnessy, John D.

AU - Cartron, Marie Astrid

AU - Haessler, Jeff

AU - Anaissie, Elias

AU - Van Rhee, Frits

AU - Crowley, John

AU - Barlogie, Bart

PY - 2009/6

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AB - The clinical significance of cytogenetic abnormalities (CA) present in randomly sampled (RS) or focal lesion (FL) bone marrow sites was examined in 419 untreated myeloma patients. Among 290 patients with gene expression profiling (GEP) data generated from RS sites, GEP-defined high-risk was present in 52% of the RS+/FL+ group but in only 9% of the remainder (P < 0·001). The RS+/FL+ constellation (18%) was an independent predictor of poor survival, also after adjusting for GEP-derived risk and TP53 status (Hazard ratio = 2·42, P = 0·004). The prevalence of high-risk myeloma in the RS+/FL+ group may reflect a dissemination-prone condition not shared by the other three groups.

KW - Cytogenetics

KW - Focal lesions

KW - Gene array

KW - Myeloma

KW - Prognosis

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Cytogenetic abnormalities in multiple myeloma: poor prognosis linked to concomitant detection in random and focal lesion bone marrow samples and associated with high-risk gene expression profile

Abstract

Keywords

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