Cystic disease of the kidney

Patricia D. Wilson, Beatrice Goilav

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

68 Scopus citations


This review focuses on the mechanisms that underlie the development of human renal cystic diseases. A pathological, clinical, and pathophysiological overview is given. Initial analysis of the cell biology of inappropriate hyperproliferation accompanied by fluid secretion of cyst-lining epithelia has been followed by the elucidation of fundamental defects in epithelial polarity, cell-matrix and cell-cell interactions, and apoptosis, all of which are discussed. Identification of the genes and proteins responsible for several renal cystic diseases has led to a more complete understanding of defects in renal developmental programming, differentiation, and morphogenesis, all of which underlie cystic diseases of the kidney.

Original languageEnglish
Title of host publicationAnnual Review of Pathology
Subtitle of host publicationMechanisms of Disease
PublisherAnnual Reviews Inc.
Number of pages28
ISBN (Print)0824343026, 9780824343026
StatePublished - 2007

Publication series

NameAnnual Review of Pathology
ISSN (Print)1553-4006
ISSN (Electronic)1553-4014


  • Autosomal polycystic kidney disease
  • Cilia
  • Differentiation
  • Epithelial polarity
  • Genes
  • Pathophysiology
  • Proteins


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