TY - JOUR
T1 - Cystatin C and baseline renal function among HIV-infected persons in the SUN study
AU - Overton, Edgar Turner
AU - Patel, Pragna
AU - Mondy, Kristin
AU - Bush, Tim
AU - Conley, Lois
AU - Rhame, Frank
AU - Kojic, Erna Milunka
AU - Hammer, John
AU - Henry, Keith
AU - Brooks, John T.
PY - 2012/2/1
Y1 - 2012/2/1
N2 - In the combination antiretroviral therapy (cART) era, renal dysfunction remains common. The Study to Understand the Natural History of HIV/AIDS in the Era of Effective Therapy (SUN) (ClinicalTrials.gov number, NCT00146419) is a prospective observational cohort study of HIV-infected adults. At baseline, comprehensive data were collected, including cystatin C and measures of renal function. Univariate and multivariate regression analyses were performed to identify factors associated with baseline renal dysfunction [estimated glomerular filtration rate (eGFR) <90 ml/min/1.73 m 2 calculated using the simplified Modification of Diet in Renal Disease equation] and elevated cystatin C (>1.0 mg/liter) in a cross-sectional analysis. Among 670 subjects with complete data (mean age 41 years, mean CD4 cell count 530 cells/mm 3, 79% prescribed cART), the mean eGFR was 96.8 ml/min/1.73 m 2. Forty percent of subjects had renal dysfunction; 3.3% had chronic kidney disease (eGFR <60 ml/min/1.73 m 2). Elevated cystatin C was present in 18% of subjects. In multivariate analysis, renal dysfunction was associated with older age, non-Hispanic white race/ethnicity, higher body mass index (BMI), hypertension, higher cystatin C levels, and current prescription of ritonavir. Factors associated with elevated cystatin C included hepatitis C coinfection, hypertension, current smoking, older age, current tenofovir use, detectable plasma HIV RNA, and elevated microalbuminuria. The prevalence of chronic kidney disease (CKD) was low in this contemporary HIV cohort. However, mild to moderate renal dysfunction was common despite the widespread use of cART.
AB - In the combination antiretroviral therapy (cART) era, renal dysfunction remains common. The Study to Understand the Natural History of HIV/AIDS in the Era of Effective Therapy (SUN) (ClinicalTrials.gov number, NCT00146419) is a prospective observational cohort study of HIV-infected adults. At baseline, comprehensive data were collected, including cystatin C and measures of renal function. Univariate and multivariate regression analyses were performed to identify factors associated with baseline renal dysfunction [estimated glomerular filtration rate (eGFR) <90 ml/min/1.73 m 2 calculated using the simplified Modification of Diet in Renal Disease equation] and elevated cystatin C (>1.0 mg/liter) in a cross-sectional analysis. Among 670 subjects with complete data (mean age 41 years, mean CD4 cell count 530 cells/mm 3, 79% prescribed cART), the mean eGFR was 96.8 ml/min/1.73 m 2. Forty percent of subjects had renal dysfunction; 3.3% had chronic kidney disease (eGFR <60 ml/min/1.73 m 2). Elevated cystatin C was present in 18% of subjects. In multivariate analysis, renal dysfunction was associated with older age, non-Hispanic white race/ethnicity, higher body mass index (BMI), hypertension, higher cystatin C levels, and current prescription of ritonavir. Factors associated with elevated cystatin C included hepatitis C coinfection, hypertension, current smoking, older age, current tenofovir use, detectable plasma HIV RNA, and elevated microalbuminuria. The prevalence of chronic kidney disease (CKD) was low in this contemporary HIV cohort. However, mild to moderate renal dysfunction was common despite the widespread use of cART.
UR - http://www.scopus.com/inward/record.url?scp=84858055332&partnerID=8YFLogxK
U2 - 10.1089/aid.2011.0018
DO - 10.1089/aid.2011.0018
M3 - Article
C2 - 21480819
AN - SCOPUS:84858055332
SN - 0889-2229
VL - 28
SP - 148
EP - 155
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
IS - 2
ER -