Cyclooxygenase and inflammation in Alzheimer's disease: Experimental approaches and clinical interventions

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Abstract

Many epidemiological studies suggest that use of non-steroidal anti- inflammatory drugs (NSAIDs) delay or slow the clinical expression of Alzheimer's disease (AD). While it has been demonstrated that neurodegeneration in AD is accompanied by specific inflammatory mechanisms, including activation of the complement cascade and the accumulation and activation of microglia, the mechanism by which NSAIDs might affect these or other pathophysiological processes relevant to AD has been unclear. New evidence that cyclooxygenase (COX) is involved in neurodegeneration along with the development of selective COX inhibitors has led to renewed interest in the therapeutic potential of NSAIDs in AD.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalJournal of Neuroscience Research
Volume54
Issue number1
DOIs
StatePublished - 1 Oct 1998

Keywords

  • Alzheimer's disease
  • Cyclooxygenase
  • Inflammation
  • NSAIDs
  • Oxidative stress

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