TY - JOUR
T1 - Cyclooxygenase-2 gene polymorphisms and susceptibility to colorectal cancer in a Brazilian population
AU - Tomitão, Michele Tatiana Pereira
AU - Nahas, Sergio Carlos
AU - Kubrusly, Marcia Saldanha
AU - Furuya, Tatiane Katsue
AU - Diniz, Marcio Augusto
AU - Marie, Suely Kazue Nagahashi
AU - Safatle-Ribeiro, Adriana Vaz
AU - Eluf-Neto, José
AU - Cecconello, Ivan
AU - Junior, Ulysses Ribeiro
N1 - Publisher Copyright:
© Journal of Gastrointestinal Oncology.
PY - 2017/8/1
Y1 - 2017/8/1
N2 - Background: Multi-ethnicity of Brazilian population displays high levels of genomic diversity. Polymorphism may detect people at higher risk of developing cancer, distinctive response to treatment, and prognosis. Cyclooxygenase-2 (COX-2) is induced in response to growth factors and cytokines, and is expressed in inflammatory diseases, precancerous lesions and colorectal cancer (CRC). The aim of this study was to evaluate the influence of COX-2-1195A > G and 8473T > C polymorphisms as a risk factor of developing CRC. Methods: We evaluated COX-2 Single Nucleotide Polymorphism (SNP) of 230 CRC patients and 196 healthy controls by Real-Time Polymerase Chain Reaction. Results: Populations were in Hardy-Weinberg equilibrium (HWE), except for control group of 8473T > C SNP. The frequencies were similar in both groups for genotypes and haplotypes. There was no association between studied polymorphisms and risk of CRC. Conclusions: The gene polymorphisms studied do not participate in the genetic susceptibility to CRC in a Brazilian population.
AB - Background: Multi-ethnicity of Brazilian population displays high levels of genomic diversity. Polymorphism may detect people at higher risk of developing cancer, distinctive response to treatment, and prognosis. Cyclooxygenase-2 (COX-2) is induced in response to growth factors and cytokines, and is expressed in inflammatory diseases, precancerous lesions and colorectal cancer (CRC). The aim of this study was to evaluate the influence of COX-2-1195A > G and 8473T > C polymorphisms as a risk factor of developing CRC. Methods: We evaluated COX-2 Single Nucleotide Polymorphism (SNP) of 230 CRC patients and 196 healthy controls by Real-Time Polymerase Chain Reaction. Results: Populations were in Hardy-Weinberg equilibrium (HWE), except for control group of 8473T > C SNP. The frequencies were similar in both groups for genotypes and haplotypes. There was no association between studied polymorphisms and risk of CRC. Conclusions: The gene polymorphisms studied do not participate in the genetic susceptibility to CRC in a Brazilian population.
KW - Colorectal cancer (CRC)
KW - Cyclooxygenase-2 (COX-2)
KW - Genes
KW - Polymorphism
KW - Risk
KW - Single nucleotide polymorphism (SNP)
KW - Susceptibility
UR - http://www.scopus.com/inward/record.url?scp=85027305973&partnerID=8YFLogxK
U2 - 10.21037/jgo.2017.03.05
DO - 10.21037/jgo.2017.03.05
M3 - Article
AN - SCOPUS:85027305973
SN - 2078-6891
VL - 8
SP - 629
EP - 635
JO - Journal of Gastrointestinal Oncology
JF - Journal of Gastrointestinal Oncology
IS - 4
ER -