Cyclic-AMP production by polymorphonuclear leukocytes in psychiatric disorders

The cyclic adenosine monophosphate (cAMP) responses to histamine, prostaglandin-E₁, and isoproterenol in polymorphonuclear leukocytes from drug-free normal controls and patients with schizophrenia or major depressive disorder were compared. These three groups of subjects did not differ in their cAMP responses to receptor activation. Exacerbated and remitted patients with either schizophrenia or major depressive disorder did not differ in their cAMP responses. The data indicate that in polymorphonuclear leukocytes, the cAMP responses to activation of histamine H₂, prostaglandin-E₁, or betaadrenergic receptors are neither state-independent nor state-dependent markers for schizophrenia or major depressive disorder.